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Article
Open AccessCD200 is overexpressed in the pancreatic tumor microenvironment and predictive of overall survival
Pancreatic cancer is an aggressive disease with a 5 year survival rate of 13%. This poor survival is attributed, in part, to limited and ineffective treatments for patients with metastatic disease, highlightin...
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Article
Fibroblast pyruvate carboxylase is required for collagen production in the tumour microenvironment
The aberrant production of collagen by fibroblasts is a hallmark of many solid tumours and can influence cancer progression. How the mesenchymal cells in the tumour microenvironment maintain their production o...
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Article
Open AccessThe small G-protein RalA promotes progression and metastasis of triple-negative breast cancer
Breast cancer (BC) is the most common cancer in women and the leading cause of cancer-associated mortality in women. In particular, triple-negative BC (TNBC) has the highest rate of mortality due in large part...
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Article
Open AccessGenomic features of rapid versus late relapse in triple negative breast cancer
Triple-negative breast cancer (TNBC) is a heterogeneous disease and we have previously shown that rapid relapse of TNBC is associated with distinct sociodemographic features. We hypothesized that rapid versus ...
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Article
Open AccessAbrupt involution induces inflammation, estrogenic signaling, and hyperplasia linking lack of breastfeeding with increased risk of breast cancer
A large collaborative analysis of data from 47 epidemiological studies concluded that longer duration of breastfeeding reduces the risk of develo** breast cancer. Despite the strong epidemiological evidence,...
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Article
Open AccessPTEN expression by an oncolytic herpesvirus directs T-cell mediated tumor clearance
Engineered oncolytic viruses are used clinically to destroy cancer cells and have the ability to boost anticancer immunity. Phosphatase and tensin homolog deleted on chromosome 10 loss is common across a broad...
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Article
Open AccessPyruvate kinase M2 regulates homologous recombination-mediated DNA double-strand break repair
Resistance to genotoxic therapies is a primary cause of treatment failure and tumor recurrence. The underlying mechanisms that activate the DNA damage response (DDR) and allow cancer cells to escape the lethal...
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Article
Open AccessStromal PTEN determines mammary epithelial response to radiotherapy
The importance of the tumor–associated stroma in cancer progression is clear. However, it remains uncertain whether early events in the stroma are capable of initiating breast tumorigenesis. Here, we show that...
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Article
The ETS family of oncogenic transcription factors in solid tumours
ETS factor expression is aberrantly upregulated in solid tumours through chromosomal translocation and amplification.
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Article
Hypomethylation of the MMP7 promoter and increased expression of MMP7 distinguishes the basal-like breast cancer subtype from other triple-negative tumors
Identification of novel targets for the treatment of basal-like breast cancer is essential for improved outcomes in patients with this disease. This study investigates the association of MMP7 expression and MMP7 ...
