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  1. Article

    Open Access

    Hotspots of aberrant enhancer activity punctuate the colorectal cancer epigenome

    In addition to mutations in genes, aberrant enhancer element activity at non-coding regions of the genome is a key driver of tumorigenesis. Here, we perform epigenomic enhancer profiling of a cohort of more th...

    Andrea J. Cohen, Alina Saiakhova, Olivia Corradin… in Nature Communications (2017)

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  2. No Access

    Article

    Modeling disease risk through analysis of physical interactions between genetic variants within chromatin regulatory circuitry

    Peter Scacheri and colleagues identify ‘outside’ SNPs that physically interact with GWAS risk SNPs as part of a target gene's regulatory circuitry. Their findings suggest a model whereby outside variants and G...

    Olivia Corradin, Andrea J Cohen, Jennifer M Luppino, Ian M Bayles… in Nature Genetics (2016)

  3. No Access

    Chapter

    The Expression of ICAM-1 and P-Selectin Are Increased Following Hemorrhage and Resuscitation in Mice

    Acute inflammatory lung injury is a common clinical occurrence following trauma and blood loss and is characterized by massive neutrophil infiltration into the lungs. The mechanisms responsible for the increas...

    Andrea J. Cohen, Robert Shenkar, Dietmar Vestweber… in Acute Respiratory Distress Syndrome (1998)