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Article
Open AccessCHD7 promotes neural progenitor differentiation in embryonic stem cells via altered chromatin accessibility and nascent gene expression
CHARGE syndrome, a rare multiple congenital anomaly condition, is caused by haploinsufficiency of the chromatin remodeling protein gene CHD7 (Chromodomain helicase DNA binding protein 7). Brain abnormalities and ...
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Article
Enhancer map** uncovers phenotypic heterogeneity and evolution in patients with luminal breast cancer
The degree of intrinsic and interpatient phenotypic heterogeneity and its role in tumor evolution is poorly understood. Phenotypic drifts can be transmitted via inheritable transcriptional programs. Cell-type ...
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Article
Open AccessColon Cancer-Upregulated Long Non-Coding RNA lincDUSP Regulates Cell Cycle Genes and Potentiates Resistance to Apoptosis
Long non-coding RNAs (lncRNAs) are frequently dysregulated in many human cancers. We sought to identify candidate oncogenic lncRNAs in human colon tumors by utilizing RNA sequencing data from 22 colon tumors a...
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Article
Correction: Corrigendum: Positively selected enhancer elements endow osteosarcoma cells with metastatic competence
Nat. Med. 24, 176–185 (2018); published online 15 January 2018; corrected after print 7 February 2018 In the version of this article initially published, two of the authors are incorrectly identified as John S...
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Article
Positively selected enhancer elements endow osteosarcoma cells with metastatic competence
Peter Scacheri and colleagues report that the activity of enhancer elements in metastatic osteosarcoma is distinct from that in primary tumors and plays a functional role in metastatic progression of osteosarc...
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Therapeutic targeting of ependymoma as informed by oncogenic enhancer profiling
Super enhancers regulate oncogenes and other molecular targets in ependymomas, and identification of these genes provides potential therapeutic targets.
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Open AccessHotspots of aberrant enhancer activity punctuate the colorectal cancer epigenome
In addition to mutations in genes, aberrant enhancer element activity at non-coding regions of the genome is a key driver of tumorigenesis. Here, we perform epigenomic enhancer profiling of a cohort of more th...
