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    Article

    Pharmacokinetics of oral entacapone after frequent multiple dosing and effects on levodopa disposition

    Objective: Entacapone is a peripherally acting catechol O-methyltransferase (COMT) inhibitor used as an adjunct to each daily levodopa/dopa decarboxylase (DDC) inhibitor dose in the trea...

    J. Rouru, A. Gordin, R. Huupponen, S. Huhtala in European Journal of Clinical Pharmacology (1999)

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    Article

    A double-blind study of MPV-2213ad, a novel aromatase inhibitor, in healthy male subjects

    Objective: Novel aromatase inhibitors are developed with requirements of high potency and selectivity for the aromatase enzyme. The hormonal effects of a new, non-steroidal competitive i...

    O. Ahokoski, K. Irjala, S. Huhtala in European Journal of Clinical Pharmacology (1999)

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    Article

    Aqueous humour concentration and the intraocular pressure-lowering effect of topical betaxolol before cataract surgery

    Objective: The aim was to study the relationship between aqueous humour betaxolol concentration and intraocular pressure (IOP).

    E. Vainio-Jylhä, M.-L. Vuori, T. Kaila in European Journal of Clinical Pharmacology (1998)

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    Article

    Kinetics of propiverine as assessed by radioreceptor assay in poor and extensive metabolizers of debrisoquine

    A pharmacokinetic study with 30 mg propiverine p.o. was performed in healthy volunteers (10 males, 6 females, age 36–56 years, body weight 55–100 kg, body height 162–184 cm, Broca index 0.96–1.19). 8 of them w...

    C. Müller, W. Siegmund, R. Huupponen in European Journal of Drug Metabolism and Ph… (1993)

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    Article

    The relationship between debrisoquine oxidation phenotype and the pharmacokinetics of chlorpropamide

    The pharmacokinetics and urinary metabolite pattern of a single oral dose of chlorpropamide 250 mg have been studied in 6 extensive and 5 poor metabolizers of debrisoquine. Ammonium chloride was given orally t...

    J. Kallio MD, R. Huupponen, K. Pyykkö in European Journal of Clinical Pharmacology (1990)

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    Article

    Effect of guar gum on glipizide absorption in man

    The effect of 4.75 g guar gum, a fibre preparation, on the absorption of 2.5 mg glipizide has been studied in 10 healthy volunteers given a standard breakfast. Three different experimental protocols were used:...

    R. Huupponen, S. Karhuvaara, P. Seppälä in European Journal of Clinical Pharmacology (1985)

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    Article

    Effect of guar gum, a fibre preparation, on digoxin and penicillin absorption in man

    The effect of guar gum on the absorption of digoxin and phenoxymethyl penicillin was studied in a double blind study in 10 healthy volunteers. Guar gum reduced serum digoxin concentration during the early abso...

    R. Huupponen, P. Seppälä, E. Iisalo in European Journal of Clinical Pharmacology (1984)