8 Result(s)
within
Philippe Pierre
Science, Humanities and Social Sciences, multidisciplinary
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Article
Open AccessRUFY3 regulates endolysosomes perinuclear positioning, antigen presentation and migration in activated phagocytes
Endo-lysosomes transport along microtubules and clustering in the perinuclear area are two necessary steps for microbes to activate specialized phagocyte functions. We report that RUN and FYVE domain-containing p...
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Article
Open AccessDistinct metabolic states guide maturation of inflammatory and tolerogenic dendritic cells
Cellular metabolism underpins immune cell functionality, yet our understanding of metabolic influences in human dendritic cell biology and their ability to orchestrate immune responses is poorly developed. Her...
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Article
Open AccessBAD-LAMP controls TLR9 trafficking and signalling in human plasmacytoid dendritic cells
Toll-like receptors (TLR) are essential components of the innate immune system. Several accessory proteins, such as UNC93B1, are required for transport and activation of nucleic acid sensing Toll-like receptor...
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Article
Open AccessMRF4 negatively regulates adult skeletal muscle growth by repressing MEF2 activity
The myogenic regulatory factor MRF4 is highly expressed in adult skeletal muscle but its function is unknown. Here we show that Mrf4 knockdown in adult muscle induces hypertrophy and prevents denervation-induced ...
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Article
Open AccessGCN2 contributes to mTORC1 inhibition by leucine deprivation through an ATF4 independent mechanism
It is well known that the GCN2 and mTORC1 signaling pathways are regulated by amino acids and share common functions, in particular the control of translation. The regulation of GCN2 activity by amino acid ava...
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Article
Exaggerated translation causes synaptic and behavioural aberrations associated with autism
Mice overexpressing eIF4E show autism-related behaviours and altered synaptic activity in the hippocampus, prefrontal cortex and striatum, and these phenotypes can be rescued with the cap-dependent translation...
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Article
Transient aggregation of ubiquitinated proteins during dendritic cell maturation
Dendritic cells (DCs) are antigen-presenting cells with the unique capacity to initiate primary immune responses1. Dendritic cells have a remarkable pattern of differentiation (maturation) that exhibits highly sp...
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Article
Developmental regulation of MHC class II transport in mouse dendritic cells
Dendritic cells (DCs) have the unique capacity to initiate primary and secondary immune responses1,2,3. They acquire antigens in peripheral tissues and migrate to lymphoid organs where they present processed pept...
