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Article
Highly Variable Paracetamol Pharmacokinetics After Multiple Oral Dosing in Frail Older People: A Population Pharmacokinetic Analysis
Paracetamol pharmacokinetics (PK) is highly variable in older fit adults after intravenous administration. Frailty and oral administration likely result in additional variability. The aim was to determine oral...
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Article
Insights Image for “Repetitive noxious stimuli during early development affect acute and long-term mechanical sensitivity in rats”
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Article
Repetitive noxious stimuli during early development affect acute and long-term mechanical sensitivity in rats
Prematurely born infants are frequently exposed to painful procedures in the neonatal intensive care unit, causing changes to the development of the nervous system lasting into adulthood. The current study aim...
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Article
Open AccessScaling Drug Clearance from Adults to the Young Children for Drugs Undergoing Hepatic Metabolism: A Simulation Study to Search for the Simplest Scaling Method
Previous research showed that scaling drug clearance from adults to children based on body weight alone is not accurate for all hepatically cleared drugs in very young children. This study systematically asses...
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Article
Open AccessPopulation pharmacokinetics of haloperidol in terminally ill adult patients
Over 80% of the terminally ill patients experience delirium in their final days. In the treatment of delirium, haloperidol is the drug of choice. Very little is known about the pharmacokinetics of haloperidol ...
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Article
Open AccessAnalgosedation in paediatric severe traumatic brain injury (TBI): practice, pitfalls and possibilities
Analgosedation is a fundamental part of traumatic brain injury (TBI) treatment guidelines, encompassing both first and second tier supportive strategies. Worldwide analgosedation practices continue to be heter...
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Article
Changes in thyroid hormone concentrations during neonatal extracorporeal membrane oxygenation
Thyroid hormone concentrations can be disturbed during critical illness. Our aim was to determine changes in thyroid hormone concentrations during neonatal extracorporeal membrane oxygenation (ECMO).
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Article
Children’s outcomes at 2-year follow-up after 4 years of structured multi-professional medical-ethical decision-making in a neonatal intensive care unit
We reviewed our decisions about continuation/withdrawal of life-sustaining treatments in a group of critically ill newborns who were discussed in structured medical ethical decision-making meetings, and provid...
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Article
Open AccessThe vulnerable microcirculation in the critically ill pediatric patient
In neonates, cardiovascular system development does not stop after the transition from intra-uterine to extra-uterine life and is not limited to the macrocirculation. The microcirculation (MC), which is essent...
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Article
Open AccessCutaneous microcirculation in preterm neonates: comparison between sidestream dark field (SDF) and incident dark field (IDF) imaging
Incident dark field imaging (IDF) is a new generation handheld microscope for bedside visualization and quantification of microcirculatory alterations. IDF is the technical successor of sidestream dark field i...
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Article
Adverse events of haloperidol for the treatment of delirium in critically ill children
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Article
Open AccessLumbar spine and total-body dual-energy X-ray absorptiometry in children with severe neurological impairment and intellectual disability: a pilot study of artefacts and disrupting factors
Children with severe neurological impairment and intellectual disability (ID) are susceptible for develo** low bone mineral density (BMD) and fractures. BMD is generally measured with dual-energy X-ray absor...
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Article
Open AccessDeterminants of drug absorption in different ECMO circuits
The aim of this in vitro study was to evaluate potential determinants of drug loss in different ECMO circuits.
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Article
144 Incidence, Risk Factors and Severity of Pulmonary Morbidity in Infants with Congenital Diaphragmatic Hernia Born in High-Volume Centres in Europe
Background and aims: Newborns with congenital diaphragmatic hernia (CDH) may develop chronic lung disease (CLD). Our aim was to determine the incidence, severity and risk factors of CLD in infants with CDH.
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Article
Open AccessFeasibility of sedation and analgesia interruption following cannulation in neonates on extracorporeal membrane oxygenation
In most extracorporeal membrane oxygenation (ECMO) centers patients are heavily sedated to prevent accidental decannulation and bleeding complications. In ventilated adults not on ECMO, daily sedation interrup...
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Article
Open AccessCan we improve outcome of congenital diaphragmatic hernia?
This review gives an overview of the disease spectrum of congenital diaphragmatic hernia (CDH). Etiological factors, prenatal predictors of survival, new treatment strategies and long-term morbidity are descri...
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Article
Children with intellectual disabilities and pain perception: A review and suggestions for future assessment protocols
AIM: This was to review what is known about pain assessment in children with intellectual disabilities and to translate findings into clinical dental practice. METHODS: Literature review. REVIEW:...
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Article
Propofol pharmacokinetics in preterm and term neonates: the relevance of both postmenstrual and postnatal age
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Article
Effects of low-dose naloxone on opioid therapy in pediatric patients: a retrospective case-control study
To develop novel therapies that prevent opioid tolerance in critically ill children we examined the effects of low-dose naloxone infusions on patients' needs for analgesia or sedation.
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Chapter and Conference Paper
Patient Safety Management System in Pediatric ICUs
The multidisciplinary approach of the project is improving patient safety by continuous quality assessment and modification guided by monthly, real data. Cost effectiveness of patient safety management systems...
