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Article
Open AccessComparison of antipsychotic drug use among Dutch Youth before and after implementation of the Youth Act (2010–2019)
The Dutch law on youth care (the Youth Act) was implemented from 2015 onwards. One of the government’s aims by implementing this new policy was de-medicalization of youths by separating youth mental healthcare...
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Article
Open AccessBody composition is associated with tacrolimus pharmacokinetics in kidney transplant recipients
A population pharmacokinetic (popPK) model may be used to improve tacrolimus dosing and minimize under- and overexposure in kidney transplant recipients. It is unknown how body composition parameters relate to...
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Article
Highly Variable Paracetamol Pharmacokinetics After Multiple Oral Dosing in Frail Older People: A Population Pharmacokinetic Analysis
Paracetamol pharmacokinetics (PK) is highly variable in older fit adults after intravenous administration. Frailty and oral administration likely result in additional variability. The aim was to determine oral...
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Article
Open AccessPopulation pharmacokinetics of haloperidol in terminally ill adult patients
Over 80% of the terminally ill patients experience delirium in their final days. In the treatment of delirium, haloperidol is the drug of choice. Very little is known about the pharmacokinetics of haloperidol ...
