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Article
Open AccessFluoropyrimidine type, patient age, tumour sidedness and mutation status as determinants of benefit in patients with metastatic colorectal cancer treated with EGFR monoclonal antibodies: individual patient data pooled analysis of randomised trials from the ARCAD database
KRAS mutations in metastatic colorectal cancer (mCRC) are used as predictive biomarkers to select therapy with EGFR monoclonal antibodies (mAbs). Other factors may be significant determinants of benefit.
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Article
Prestatiedruk en schoolstress bekeken vanuit verschillende perspectieven
Jongeren ervaren de laatste jaren steeds meer schoolstress en druk door school. Om goed inzicht te krijgen in de factoren die ten grondslag liggen aan deze toename en mogelijk een schakel zijn voor verandering...
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Article
Open AccessEscherichia coli from urine samples of pregnant women as an indicator for antimicrobial resistance in the community: a field study from rural Burkina Faso
In low- and middle-income countries, surveillance of antimicrobial resistance (AMR) is mostly hospital-based and, in view of poor access to clinical microbiology, biased to more resistant pathogens. We aimed t...
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Article
Open AccessDifferences in Adolescents’ Alcohol Use and Smoking Behavior between Educational Tracks: Do Popularity Norms Matter?
Explanations about differences in drinking and smoking rates between educational tracks have so far mainly focused on factors outside the classroom. The extent to which these behaviors are rewarded with popula...
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Article
Open AccessSoil-transmitted helminth infections in free-ranging non-human primates from Cameroon and Gabon
Zoonotic diseases are a serious threat to both public health and animal conservation. Most non-human primates (NHP) are facing the threat of forest loss and fragmentation and are increasingly living in closer ...
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Chapter and Conference Paper
Integration of Catalytic Biofuel Production and Anaerobic Digestion for Biogas Production
The drive towards a low carbon economy will lead to an increase in new lignocellulosic biorefinery activities. Integration of biorefinery waste products into established bioenergy technologies could lead to sy...
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Article
Open AccessSolid residue and by-product yields from acid-catalysed conversion of poplar wood to levulinic acid
This study examines the yields of solid residue and by-product from the microwave-assisted acid hydrolysis of lignocellulosic poplar wood for levulinic acid production. The aim of this study was to optimise le...
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Article
Should Anti-EGFR Agents Be Used in Right-Sided RAS Wild-type Advanced Colorectal Cancer?
Colorectal cancer is the third most common cancer worldwide with a high mortality rate at the advanced stages of the disease. Treatment options are dependent on the stage of the disease, patients’ performance ...
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Chapter
Analysis of the Aerodynamic Loads on a Wind Turbine in Off-Design Conditions
In this work, the aerodynamic loads acting on a large horizontal axis wind turbine are analysed in off-design conditions by means of computational fluid dynamics (CFD) simulations. The turbulent wind flow is s...
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Article
Development of a Flexible MIP-Based Biosensor Platform for the Thermal Detection of Neurotransmitters
We have developed high affinity Molecularly Imprinted Polymers (MIPs) for neurotransmitters such as dopamine, noradrenaline and caffeine. These polymer particles are mixed within the bulk of screen-printed ink...
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Chapter
Liquid Biopsy in Colorectal Cancer
Colorectal cancer (CRC) is the third most common cancer worldwide. Oncological CRC treatment is changing gradually replacing ancient drugs with the newest targeted agents (target therapy) and immunotherapy. Th...
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Chapter
CRC Liver Metastases
The liver is the most common metastatic site in patients with colorectal carcinoma (CRC) [1]. Twenty-five per cent (25 %) of CRC patients have clinically detectable liver metastases at the initial diagnosis an...
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Article
Impact of genetic variability and treatment-related factors on outcome in early breast cancer patients receiving (neo-) adjuvant chemotherapy with 5-fluorouracil, epirubicin and cyclophosphamide, and docetaxel
To assess the impact of patient-related factors, including genetic variability in genes involved in the metabolism of chemotherapeutic agents, on breast cancer-specific survival (BCSS) and recurrence-free int...
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Article
Open AccessDetection and prognostic significance of circulating tumour cells in patients with metastatic breast cancer according to immunohistochemical subtypes
The enumeration of circulating tumour cells (CTCs) with the EpCAM-based CellSearch system has prognostic significance in patients with metastatic breast cancer (MBC). The aim of this study was to explore poten...
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Article
Molecularly imprinted polymers as synthetic receptors for the QCM-D-based detection of l-nicotine in diluted saliva and urine samples
Molecularly imprinted polymers (MIPs) are synthetic receptors that are able to specifically bind their target molecules in complex samples, making them a versatile tool in biosensor technology. The combination...
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Article
Heat-transfer-based detection of l-nicotine, histamine, and serotonin using molecularly imprinted polymers as biomimetic receptors
In this work, we will present a novel approach for the detection of small molecules with molecularly imprinted polymer (MIP)-type receptors. This heat-transfer method (HTM) is based on the change in heat-trans...
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Article
Standardized added metabolic activity (SAM) IN 18F-FDG PET assessment of treatment response in colorectal liver metastases
Standardized added metabolic activity (SAM) is a PET parameter for assessing the total metabolic load of malignant processes, avoiding partial volume effects and lesion segmentation. The potential role of this...
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Article
Open AccessSemiautomated isolation and molecular characterisation of single or highly purified tumour cells from CellSearch enriched blood samples using dielectrophoretic cell sorting
Molecular characterisation of single circulating tumour cells (CTCs) holds considerable promise for predictive biomarker assessment and to explore CTC heterogeneity. We evaluate a new method, the DEPArray syst...
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Article
Open AccessA randomised, double-blind, placebo-controlled phase 2 study of trebananib (AMG 386) in combination with FOLFIRI in patients with previously treated metastatic colorectal carcinoma
This phase 2 study evaluated trebananib (AMG 386), an investigational peptide-Fc fusion protein that neutralises the interaction between angiopoietins-1/2 and the Tie2 receptor, plus FOLFIRI as second-line tre...
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Article
Diagnostic testing for Legionnaires’ disease in the Netherlands between 2007 and 2009: a possible cause for the decline in reported Legionnaires’ disease patients
Legionnaires’ disease (LD) is an acute pneumonia caused by the inhalation or aspiration of aerosols contaminated with the Legionella bacteria. In the Netherlands, around 300 LD cases per year were reported betwee...
