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Article
Open AccessTRPV1 dysfunction in cystinosis patients harboring the homozygous 57 kb deletion
Cystinosis is a rare autosomal recessive disorder characterized by lysosomal cystine accumulation due to loss of function of the lysosomal cystine transporter (CTNS). The most common mutation in cystinosis pat...
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Article
Open AccessPET imaging in healthy subjects and migraineurs suggests CGRP receptor antagonists do not have to act centrally to achieve clinical efficacy
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Open AccessCapsaicin-induced CGRP-mediated vasodilatation of the human skin: influence of gender, female hormones and migraine
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Cefazolin plasma protein binding and its covariates in neonates
Cefazolin (CFZ) is highly and saturably bound to human serum albumin (HSA) in adults. We aim to describe CFZ protein binding and its covariates in neonates. In neonates to whom intravenous CFZ (50 mg/kg) was a...
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Article
Voriconazole plasma levels in children are highly variable
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Article
Open AccessP2.13 The form Factor (FF) of Pressure Waveforms in a Young Population: Difference Between Men and Women
Bos et al stated that the well known one-third rule for the calculation of mean arterial pressure (MAP) from diastolic (DBP) and pulse pressure (PP) underestimates the MAP. We calculated the percentage (form f...
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Propofol pharmacokinetics in preterm and term neonates: the relevance of both postmenstrual and postnatal age
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Postmenstrual age and CYP2D6 polymorphisms determine urinary tramadol O-demethylation excretion in critically ill neonates and infants
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Article
O-demethylation of tramadol in the first months of life
Assess in vivo O-demethylation activity in the first months of life.
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Tramadol concentrations in blood and in cerebrospinal fluid in a neonate
Based on blood and cerebrospinal fluid samples collected in a full-term neonate, the penetration of tramadol in the central nervous system is described. Following intravenous administration of tramadol, a lag ...
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Article
7 Ontogeny of Udp-Glucuronosyltransferase Activity During Repeated Administration of Propacetamol in Neonates
Background: Major changes in drug clearance are observed during infancy, at least partially based on ontogenic regulation of metabolic pathways but data on maturation of UDP-glucuronosyltransferase (UGT)-activity...
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Article
Non-invasive assessment of selective 5-HT1B/1D-receptor agonist-induced peripheral vascular effects in humans: comparison of different techniques
Abstract
