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  1. No Access

    Article

    Cefazolin plasma protein binding and its covariates in neonates

    Cefazolin (CFZ) is highly and saturably bound to human serum albumin (HSA) in adults. We aim to describe CFZ protein binding and its covariates in neonates. In neonates to whom intravenous CFZ (50 mg/kg) was a...

    A. Smits, A. Kulo, R. Verbesselt… in European Journal of Clinical Microbiology … (2012)

  2. Article

    Propylene Glycol Pharmacokinetics and Renal Elimination Capacity: Preliminary Observations

    Introduction: Unintended propylene glycol (PG) administration (34 mg/kg/24h) did not affect postnatal adaptations [1]. Subsequently, we aim to document PG disposition in neonates.

    A Kulo, V Cossey, J N De Hoon, R Verbesselt, K Allegaert in Pediatric Research (2011)

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  3. No Access

    Article

    Voriconazole plasma levels in children are highly variable

    I. Spriet, K. Cosaert, M. Renard… in European Journal of Clinical Microbiology … (2011)

  4. Article

    473 Prospective Evaluation of Propylene Glycol Tolerance in (PRE) Term Neonates: An Active Comparator Approach

    Introduction: Propylene glycol (PG) is a commonly used excipiens although accumulation can result in hyperosmolarity, renal toxicity and lactic acidosis. This is of concern in neonates given their limited meta...

    K Allegaert, J D Hoon, M Rayyan, R Verbesselt, V Cossey, G Naulaers in Pediatric Research (2010)

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  5. Article

    Propofol pharmacokinetics in preterm and term neonates: the relevance of both postmenstrual and postnatal age

    K Allegaert, M Peeters, R Verbesselt, D Tibboel, G Naulaers, J De Hoon… in Critical Care (2008)

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  6. Article

    Postmenstrual age and CYP2D6 polymorphisms determine urinary tramadol O-demethylation excretion in critically ill neonates and infants

    K Allegaert, R Verbesselt, R Van Schaik, J Van den Anker, C Vanhole… in Critical Care (2008)

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  7. No Access

    Article

    O-demethylation of tramadol in the first months of life

    Assess in vivo O-demethylation activity in the first months of life.

    Karel Allegaert, J. N. Van den Anker… in European Journal of Clinical Pharmacology (2005)

  8. No Access

    Article

    Tramadol concentrations in blood and in cerebrospinal fluid in a neonate

    Based on blood and cerebrospinal fluid samples collected in a full-term neonate, the penetration of tramadol in the central nervous system is described. Following intravenous administration of tramadol, a lag ...

    K Allegaert, J de Hoon, R Verbesselt… in European Journal of Clinical Pharmacology (2005)

  9. Article

    7 Ontogeny of Udp-Glucuronosyltransferase Activity During Repeated Administration of Propacetamol in Neonates

    Background: Major changes in drug clearance are observed during infancy, at least partially based on ontogenic regulation of metabolic pathways but data on maturation of UDP-glucuronosyltransferase (UGT)-activity...

    K Allegaert, D Tibboel, H Devlieger, J de Hoon, R Verbesselt… in Pediatric Research (2004)

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  10. No Access

    Article

    Block of volume-regulated anion channels by selective serotonin reuptake inhibitors

    We have used the whole-cell patch clamp technique to study the effects of the commonly used antidepressants sertraline, paroxetine, citalopram and fluvoxamine on the volume-regulated anion channel (VRAC) in e...

    C. Maertens, G. Droogmans, R. Verbesselt… in Naunyn-Schmiedeberg's Archives of Pharmaco… (2002)

  11. No Access

    Article

    Lack of a pharmacokinetic interaction between moexipril and hydrochlorothiazide

    V. Hutt, K. Michaelis, R. Verbesselt… in European Journal of Clinical Pharmacology (1996)

  12. No Access

    Article

    Moexipril does not alter the pharmacokinetics or pharmacodynamics of warfarin

    The potential effect of moexipril, a new converting enzyme inhibitor, on the pharmacokinetics and pharmacodynamics of a single dose of warfarin has been investigated.

    A. Van Hecken, R. Verbesselt, M. Depré… in European Journal of Clinical Pharmacology (1993)

  13. No Access

    Article

    Pharmacokinetic interaction between indomethacin and diflunisal

    The effect of treatment with diflunisal on the steady-state pharmacokinetics of indomethacin has been studied in 16 healthy volunteers.

    A. Van Hecken, R. Verbesselt… in European Journal of Clinical Pharmacology (1989)

  14. No Access

    Article

    Abstracts of papers clinical pharmacological meeting

    Prof. Dr. F. W. H. M. Merkus, Prof. Dr. F. W. J. Gribnau… in Pharmaceutisch Weekblad (1988)

  15. No Access

    Article

    Interaction between furosemide and the converting enzyme inhibitor benazepril in healthy volunteers

    Single oral doses of 10 mg converting enzyme inhibitor benazepril (CGS 14824A) and 40 mg furosemide were administered to 12 healthy male volunteers either separately or concomitantly. The pharmacokinetic param...

    I. De Lepeleire, A. Van Hecken, R. Verbesselt… in European Journal of Clinical Pharmacology (1988)

  16. No Access

    Article

    Comparative multiple dose kinetics of two formulations of indomethacin

    The kinetics of a controlled release (CR) formulation of indomethacin 75 mg (Indocid-Retard®) given once daily was compared with a conventional 25 mg indomethacin capsule (Indocid®) given 3 times daily for 7 days...

    R. Verbesselt, T. B. Tjandramaga, A. Mullie… in European Journal of Clinical Pharmacology (1983)

  17. No Access

    Article

    Abstracts of papers

    F. Belpaire, F. H. M. Derkx, S. M. Bryson, A. W. Kelman… in Pharmaceutisch Weekblad (1983)