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Open AccessAre higher antidepressant plasma concentrations associated with fall risk in older antidepressant users?
To explore the association between antidepressant plasma concentrations and fall risk in older users.
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Article
Open AccessIn silico evaluation of limited sampling strategies for individualized dosing of extended half-life factor IX concentrates in hemophilia B patients
Hemophilia B is a bleeding disorder, caused by a factor IX (FIX) deficiency. Recently, FIX concentrates with extended half-life (EHL) have become available. Prophylactic dosing of EHL-FIX concentrates can be o...
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Open AccessPopulation pharmacokinetics of haloperidol in terminally ill adult patients
Over 80% of the terminally ill patients experience delirium in their final days. In the treatment of delirium, haloperidol is the drug of choice. Very little is known about the pharmacokinetics of haloperidol ...
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Article
Open AccessDeterminants of drug absorption in different ECMO circuits
The aim of this in vitro study was to evaluate potential determinants of drug loss in different ECMO circuits.
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Open AccessFeasibility of sedation and analgesia interruption following cannulation in neonates on extracorporeal membrane oxygenation
In most extracorporeal membrane oxygenation (ECMO) centers patients are heavily sedated to prevent accidental decannulation and bleeding complications. In ventilated adults not on ECMO, daily sedation interrup...
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The CYP2C19*17 genotype is associated with lower imipramine plasma concentrations in a large group of depressed patients
CYP2C19 converts the tricyclic antidepressant imipramine to its active metabolite desipramine, which is subsequently inactivated by CYP2D6. The novel CYP2C19*17 allele causes ultrarapid metabolism of CYP2C19 subs...
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Association of graded allele-specific changes in CYP2D6 function with imipramine dose requirement in a large group of depressed patients
The inactivation and clearance of the tricyclic antidepressant imipramine is dependent on CYP2D6 activity. First, CYP2C19 converts imipramine into the active metabolite desipramine, which is then inactivated b...
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Article
Bepaling van de glomerulaire filtratiesnelheid bij kinderen door middel van de inuline single injectiemethode
Background. Renal function can be assessed by determination of the glomerular filtration rate (gfr). The standard method to determine gfr in children is the urinary clearance of inulin during a continuous intrave...
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Open AccessPotential for improvement of docetaxel-based chemotherapy: a pharmacological review
Since the introduction of docetaxel, research has focused on various approaches to overcome treatment limitations and improve outcome. This review discusses the pharmacological attempts at treatment optimisati...
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The relative importance of cyclosporine exposure in heart, kidney or liver transplant recipients on maintenance therapy
We investigated the relationship between cyclosporine exposure and the presence of cyclosporine-related side effects and assessed the advantage of the cyclosporine concentration 2 h post-dose (C2) over pre-dose c...
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Open AccessPhase I and pharmacokinetic study of the combination of topotecan and ifosfamide administered intravenously every 3 weeks
To determine the maximum-tolerated dose (MTD), dose-limiting toxicities, and pharmacokinetics of topotecan administered as a 30-min intravenous (i.v.) infusion over 5 days in combination with a 1-h i.v. infusi...
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Pharmacokinetic–pharmacodynamic Guided Trial Design in Oncology
The application of pharmacokinetic (PK) and pharmacodynamic (PD) modeling in drug development has emerged during the past decades and it is has been suggested that the investigation of PK–PD relationships duri...
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Time course of action of three adenosine A1 receptor agonists with differing lipophilicity in rats: comparison of pharmacokinetic, haemodynamic and EEG effects
In this study we investigated the relationship between the pharmacokinetics and the cardiovascular and electroencephalogram (EEG) effects of three adenosine agonists with differing lipophilicity. Conscious nor...
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Abstracts of papers Pharmacological Meeting
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Pharmacokinetic-pharmacodynamic modelling in pre-clinical investigations: principles and perspectives
A new approach to preclinical pharmacodynamic investigations is presented which allows, in addition to information on the nature of the pharmacological properties of new chemical entities, also important quant...
