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Article
The role of the urban system dysfunction in the assessment of seismic risk in the Mt. Etna area (Italy)
A procedure for seismic risk assessment is applied to the Mt. Etna area (eastern Sicily, Italy) through assessment of urban system dysfunction following the occurrence of an earthquake. The tool used is based ...
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Chapter and Conference Paper
Applying the Disruption Index Procedure to Evaluate the Urban Seismic Risk in the Mt. Etna Area (Italy)
The Disruption Index is used here for the assessment of urban disruption in the Mt. Etna area after a natural disaster. The first element of the procedure is the definition of the seismic input, which is based...
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Article
Sumoylation of ING2 regulates the transcription mediated by Sin3A
ING2 (inhibitor of growth 2) is a candidate tumor-suppressor gene involved in cell cycle control, apoptosis and senescence. Although the functions of ING2 within the chromatin remodeling complex Sin3A/histone ...
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Article
Functional characterization of ATAD2 as a new cancer/testis factor and a predictor of poor prognosis in breast and lung cancers
Cancer cells frequently express genes normally active in male germ cells. ATAD2 is one of them encoding a conserved factor harbouring an AAA type ATPase domain and a bromodomain. We show here that ATAD2 is highly...
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Article
The transcription factor E2F1 and the SR protein SC35 control the ratio of pro-angiogenic versus antiangiogenic isoforms of vascular endothelial growth factor-A to inhibit neovascularization in vivo
The transcription factor E2F1 has a crucial role in the control of cell growth and has been shown to regulate neoangiogenesis in a p53-dependent manner through inhibition of activity of the VEGF-A (vascular en...
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Article
Robot-assisted laparoscopic gastrectomy with D2 dissection for adenocarcinoma: initial experience with 17 patients
Robot-assisted gastrectomy has been practised so far in very few centres in the world. The aims of this study were to assess the feasibility of robot-assisted gastrectomy for adenocarcinoma with D2 lymph nodal...
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Article
E2F1 controls alternative splicing pattern of genes involved in apoptosis through upregulation of the splicing factor SC35
The transcription factor E2F1 has a key function during S phase progression and apoptosis. It has been well-demonstrated that the apoptotic function of E2F1 involves its ability to transactivate pro-apoptotic ...
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Article
Pulmonary nodule detection on MDCT images: evaluation of diagnostic performance using thin axial images, maximum intensity projections, and computer-assisted detection
This study aimed at evaluating the diagnostic benefits of maximum intensity projections (MIP) and a commercially available computed-assisted detection system (CAD) for the detection of pulmonary nodules on MDC...
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Article
E2F-1, Skp2 and cyclin E oncoproteins are upregulated and directly correlated in high-grade neuroendocrine lung tumors
The transcription factor E2F-1 plays a crucial role in the control of cellular growth. We previously reported its differential pattern of expression in human lung tumors. In this study, we have investigated th...
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Article
E2F1 induces apoptosis and sensitizes human lung adenocarcinoma cells to death-receptor-mediated apoptosis through specific downregulation of c-FLIPshort
E2F1 is a transcription factor that plays a well-documented role during S phase progression and apoptosis. We had previously postulated that the low level of E2F1 in primary lung adenocarcinoma contributes to ...
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Article
Open AccessFunctional serotonin 5–HTTLPR polymorphism is a risk factor for migraine with aura
In the present work, we report that the functional serotonin transporter gene promoter (5–HTTLPR) polymorphism is involved in migraine pathogenesis. The distribution of 5–HTTLPR genotypes was significantly dif...
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Article
Moxifloxacin monotherapy compared to amoxicillin-clavulanate plus roxithromycin for nonsevere community-acquired pneumonia in adults with risk factors
The objective of this study was to assess the efficacy and safety of moxifloxacin versus amoxicillin-clavulanate plus roxithromycin (comparator) in adult community-acquired pneumonia (CAP) patients with risk f...
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Chapter
Génomique et protéomique dans la détection précoce du cancer
Les résultats obtenus à ce jour dans le traitement du cancer du poumon restent décevants. La faible survie s’explique par une prise en charge à un stade souvent localement avancé ou métastatique, qui ne relève...
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Article
Oligomer-mediated modulation of hTERT alternative splicing induces telomerase inhibition and cell growth decline in human prostate cancer cells
The expression of telomerase in human cells is strictly controlled by multiple mechanisms including transcription and alternative splicing of telomerase reverse transcriptase (hTERT). In this study, we demons...
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Article
Open AccessDifferential expression of telomerase reverse transcriptase (hTERT) in lung tumours
Human telomerase reverse transcriptase is a ribonucleoprotein that synthesises telomeric sequences, which decrease at each cell division. In cancer cells, its activity is linked to telomere maintenance leading...
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Chapter and Conference Paper
Content-Based Classification of Digital Photos
Annotating images with a description of the content can facilitate the organization, storage and retrieval of image databases. It can also be useful in processing images, by taking into account the scene depic...
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Article
Phase I/II study of gemcitabine in association with vinorelbine for metastatic breast cancer
Background. Gemcitabine (G) and vinorelbine (V) have favorable safety profile and antitumor activity in metastatic breast cancer. To exploit their different mechanism of action and lack of overlap** toxicity, ...
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Article
Endovascular treatment of superior vena cava obstruction in patients with malignancies
The aim of this study was to report our experience on the management of superior vena cava obstruction (SVCO) secondary to malignant disease, using endovascular procedures. Twenty-six patients with SVCO due t...
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Article
A retrospective evaluation of HLA-A, B and -DRB1 matching in liver transplantation
Studies on the influence of histocompatibility in liver transplantation have not produced clear-cut results. We retrospectively studied the influence of HLA-A, B and -DRB1 matching on the survival of 517 live...
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Article
Central airway stenoses: preliminary results of spiral-CT-generated virtual bronchoscopy simulations in 29 patients
The purpose of this study was to determine the feasibility of using virtual bronchoscopy simulations to depict stenoses of the tracheobronchial tree. Virtual bronchoscopy simulations, based on ray casting, we...
