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  1. No Access

    Article

    Downregulation of ceramide synthase-6 during epithelial-to-mesenchymal transition reduces plasma membrane fluidity and cancer cell motility

    Epithelial-to-mesenchymal transition (EMT) promotes cell motility, which is important for the metastasis of malignant cells, and blocks CD95-mediated apoptotic signaling triggered by immune cells and chemother...

    V Edmond, F Dufour, G Poiroux, K Shoji, M Malleter, A Fouqué, S Tauzin… in Oncogene (2015)

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    Article

    The transcription factor E2F1 and the SR protein SC35 control the ratio of pro-angiogenic versus antiangiogenic isoforms of vascular endothelial growth factor-A to inhibit neovascularization in vivo

    The transcription factor E2F1 has a crucial role in the control of cell growth and has been shown to regulate neoangiogenesis in a p53-dependent manner through inhibition of activity of the VEGF-A (vascular en...

    G Merdzhanova, S Gout, M Keramidas, V Edmond, J-L Coll, C Brambilla… in Oncogene (2010)

  3. Article

    E2F1 controls alternative splicing pattern of genes involved in apoptosis through upregulation of the splicing factor SC35

    The transcription factor E2F1 has a key function during S phase progression and apoptosis. It has been well-demonstrated that the apoptotic function of E2F1 involves its ability to transactivate pro-apoptotic ...

    G Merdzhanova, V Edmond, S De Seranno, A Van den Broeck… in Cell Death & Differentiation (2008)

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