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Article
Open AccessDifferential expression of telomerase reverse transcriptase (hTERT) in lung tumours
Human telomerase reverse transcriptase is a ribonucleoprotein that synthesises telomeric sequences, which decrease at each cell division. In cancer cells, its activity is linked to telomere maintenance leading...
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Article
Open AccessDetection of HER-2/neu-positive circulating epithelial cells in prostate cancer patients
HER-2/neu may play a role in prostate carcinogenesis. The aim of this study was to use the expression of HER-2/neu as a molecular marker for the detection of circulating tumour cells (CTCs) in the blood of pat...
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Article
Open AccessTelomerase activation cooperates with inactivation of p16 in early head and neck tumorigenesis
Alteration of the p16/pRb pathway may cooperate with telomerase activation during cellular immortalization and tumour progression. We studied p16 expression status by immunohistochemistry and telomerase activi...