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  1. No Access

    Article

    Brain-derived neurotrophic factor Val66Met genotype and ovarian steroids interactively modulate working memory-related hippocampal function in women: a multimodal neuroimaging study

    Preclinical evidence suggests that the actions of ovarian steroid hormones and brain-derived neurotrophic factor (BDNF) are highly convergent on brain function. Studies in humanized mice document an interactio...

    S-M Wei, E B Baller, P D Kohn, J S Kippenhan, B Kolachana… in Molecular Psychiatry (2018)

  2. Article

    Open Access

    Variation in the Williams syndrome GTF2I gene and anxiety proneness interactively affect prefrontal cortical response to aversive stimuli

    Characterizing the molecular mechanisms underlying the heritability of complex behavioral traits such as human anxiety remains a challenging endeavor for behavioral neuroscience. Copy-number variation (CNV) in...

    M Jabbi, Q Chen, N Turner, P Kohn, M White, J S Kippenhan… in Translational Psychiatry (2015)

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  3. No Access

    Article

    Revisiting DARPP-32 in postmortem human brain: changes in schizophrenia and bipolar disorder and genetic associations with t-DARPP-32 expression

    Dopamine- and cAMP-regulated phosphoprotein of molecular weight 32 kDa (DARPP-32 or PPP1R1B) has been of interest in schizophrenia owing to its critical function in integrating dopaminergic and glutaminergic sign...

    Y Kunii, T M Hyde, T Ye, C Li, B Kolachana, D Dickinson… in Molecular Psychiatry (2014)

  4. No Access

    Article

    Hippocampal dysfunction in schizophrenia: association with brain-derived neurotrophic factor genotype

    D P Eisenberg, A M Ianni, S-M Wei, P D Kohn, B Kolachana, J Apud… in Molecular Psychiatry (2013)

  5. No Access

    Article

    Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism differentially predicts hippocampal function in medication-free patients with schizophrenia

    A Val66Met single-nucleotide polymorphism (SNP) in the brain-derived neurotrophic factor (BDNF) gene impairs activity-dependent BDNF release in cultured hippocampal neurons and predicts impaired memory and exagge...

    D P Eisenberg, A M Ianni, S-M Wei, P D Kohn, B Kolachana, J Apud… in Molecular Psychiatry (2013)

  6. Article

    Open Access

    Epistatic interactions of AKT1 on human medial temporal lobe biology and pharmacogenetic implications

    AKT1 controls important processes in medial temporal lobe (MTL) development and plasticity, but the impact of human genetic variation in AKT1 on these processes is not known in healthy or disease states. Here, we...

    H Y Tan, A G Chen, Q Chen, L B Browne, B Verchinski, B Kolachana… in Molecular Psychiatry (2012)

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  7. No Access

    Article

    Genetic variants in AVPR1A linked to autism predict amygdala activation and personality traits in healthy humans

    In mammals, the neuropeptide vasopressin is a key molecule for complex emotional and social behaviours. Two microsatellite polymorphisms, RS1 and RS3, near the promoter of AVPR1A, encoding the receptor subtype mo...

    A Meyer-Lindenberg, B Kolachana, B Gold, A Olsh, K K Nicodemus… in Molecular Psychiatry (2009)

  8. No Access

    Article

    COMT genotype predicts cortical-limbic D1 receptor availability measured with [11C]NNC112 and PET

    A common polymorphism (val158met) in the gene encoding catechol-O-methyltransferase (COMT) has been shown to affect dopamine (DA) tone in cortex and cortical functioning. D1 receptors are the main DA receptors in...

    M Slifstein, B Kolachana, E H Simpson, P Tabares, B Cheng, M Duvall… in Molecular Psychiatry (2008)

  9. No Access

    Article

    Genetic variation in MAOA modulates ventromedial prefrontal circuitry mediating individual differences in human personality

    Little is known about neural mechanisms underlying human personality and temperament, despite their considerable importance as highly heritable risk mediators for somatic and psychiatric disorders. To identify...

    J W Buckholtz, J H Callicott, B Kolachana, A R Hariri, T E Goldberg… in Molecular Psychiatry (2008)

  10. No Access

    Article

    COMT haplotype variation affects human prefrontal function

    A Meyer-Lindenberg, T Nichols, J H Callicott, J Ding, B Kolachana… in Molecular Psychiatry (2006)

  11. No Access

    Article

    Impact of complex genetic variation in COMT on human brain function

    Catechol-O-methyltransferase (COMT) has been shown to be critical for prefrontal dopamine flux, prefrontal cortex-dependent cognition and activation. Several potentially functional variants in the gene have been ...

    A Meyer-Lindenberg, T Nichols, J H Callicott, J Ding, B Kolachana… in Molecular Psychiatry (2006)

  12. No Access

    Article

    Transcriptional profiling in the human prefrontal cortex: evidence for two activational states associated with cocaine abuse

    CNS-focused cDNA microarrays were used to examine gene expression profiles in dorsolateral prefrontal cortex (dlPFC, Area 46) from seven individual sets of age- and post-mortem interval-matched male cocaine ab...

    E Lehrmann, J Oyler, M P Vawter, T M Hyde, B Kolachana… in The Pharmacogenomics Journal (2003)