24 Result(s)

Article

Genome-wide association study identifies a novel locus for cannabis dependence

Despite moderate heritability, only one study has identified genome-wide significant loci for cannabis-related phenotypes. We conducted meta-analyses of genome-wide association study data on 2080 cannabis-depe...

A Agrawal, Y-L Chou, C E Carey, D A A Baranger, B Zhang, R Sherva… in Molecular Psychiatry (2018)

Article

Structural alterations within cerebellar circuitry are associated with general liability for common mental disorders

Accumulating mental-health research encourages a shift in focus toward transdiagnostic dimensional features that are shared across categorical disorders. In support of this shift, recent studies have identifie...

A L Romer, A R Knodt, R Houts, B D Brigidi, T E Moffitt, A Caspi… in Molecular Psychiatry (2018)

Article

An epigenetic mechanism links socioeconomic status to changes in depression-related brain function in high-risk adolescents

Identifying biological mechanisms through which the experience of adversity emerges as individual risk for mental illness is an important step toward develo** strategies for personalized treatment and, ultim...

J R Swartz, A R Hariri, D E Williamson in Molecular Psychiatry (2017)

Article

Evidence of CNIH3 involvement in opioid dependence

Opioid dependence, a severe addictive disorder and major societal problem, has been demonstrated to be moderately heritable. We conducted a genome-wide association study in Comorbidity and Trauma Study data co...

E C Nelson, A Agrawal, A C Heath, R Bogdan, R Sherva, B Zhang… in Molecular Psychiatry (2016)

Article

Divergent responses of the amygdala and ventral striatum predict stress-related problem drinking in young adults: possible differential markers of affective and impulsive pathways of risk for alcohol use disorder

Prior work suggests that there may be two distinct pathways of alcohol use disorder (AUD) risk: one associated with positive emotion enhancement and behavioral impulsivity, and another associated with negative...

Y S Nikolova, A R Knodt, S R Radtke, A R Hariri in Molecular Psychiatry (2016)

Article

Functional genetic variants in the vesicular monoamine transporter 1 modulate emotion processing

Emotional behavior is in part heritable and often disrupted in psychopathology. Identification of specific genetic variants that drive this heritability may provide important new insight into molecular and neu...

F W Lohoff, R Hodge, S Narasimhan, A Nall, T N Ferraro, B J Mickey… in Molecular Psychiatry (2014)

Article

Convergent translational evidence of a role for anandamide in amygdala-mediated fear extinction, threat processing and stress-reactivity

Endocannabinoids are released ‘on-demand’ on the basis of physiological need, and can be pharmacologically augmented by inhibiting their catabolic degradation. The endocannabinoid anandamide is degraded by the...

O Gunduz-Cinar, K P MacPherson, R Cinar, J Gamble-George, K Sugden… in Molecular Psychiatry (2013)

Article

A neurogenetics approach to understanding individual differences in brain, behavior, and risk for psychopathology

Neurogenetics research has begun to advance our understanding of how genetic variation gives rise to individual differences in brain function, which, in turn, shapes behavior and risk for psychopathology. Desp...

R Bogdan, L W Hyde, A R Hariri in Molecular Psychiatry (2013)

Article

Morphological differences associated with a serotonin transporter polymorphism (5-HTTLPR) in rhesus macaques

H P Jedema, P J Gianaros, P J Greer, D D Kerr, S Liu, J D Higley… in Molecular Psychiatry (2010)

Article

Cognitive impact of genetic variation of the serotonin transporter in primates is associated with differences in brain morphology rather than serotonin neurotransmission

A powerful convergence of genetics, neuroimaging and epidemiological research has identified the biological pathways mediating individual differences in complex behavioral processes and the related risk for di...

H P Jedema, P J Gianaros, P J Greer, D D Kerr, S Liu, J D Higley… in Molecular Psychiatry (2010)

Article

Genetic variation in components of dopamine neurotransmission impacts ventral striatal reactivity associated with impulsivity

Individual differences in traits such as impulsivity involve high reward sensitivity and are associated with risk for substance use disorders. The ventral striatum (VS) has been widely implicated in reward pro...

E E Forbes, S M Brown, M Kimak, R E Ferrell, S B Manuck, A R Hariri in Molecular Psychiatry (2009)

Article

MET BDNF protects against morphological S allele effects of 5-HTTLPR

L Pezawas, A Meyer-Lindenberg, A L Goldman, B A Verchinski, G Chen… in Molecular Psychiatry (2008)

Article

Evidence of biologic epistasis between BDNF and SLC6A4 and implications for depression

Complex genetic disorders such as depression likely exhibit epistasis, but neural mechanisms of such gene–gene interactions are incompletely understood. 5-HTTLPR and BDNF VAL66MET, functional polymorphisms of ...

L Pezawas, A Meyer-Lindenberg, A L Goldman, B A Verchinski, G Chen… in Molecular Psychiatry (2008)

Article

Genetic variation in MAOA modulates ventromedial prefrontal circuitry mediating individual differences in human personality

Little is known about neural mechanisms underlying human personality and temperament, despite their considerable importance as highly heritable risk mediators for somatic and psychiatric disorders. To identify...

J W Buckholtz, J H Callicott, B Kolachana, A R Hariri, T E Goldberg… in Molecular Psychiatry (2008)