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Article
Open AccessDeep RNA-Seq reveals miRNome differences in mammary tissue of lactating Holstein and Montbéliarde cows
Genetic polymorphisms are known to influence milk production and composition. However, the genomic mechanisms involved in the genetic regulation of milk component synthesis are not completely understood. Micro...
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Article
Open AccessXanthine dehydrogenase downregulation promotes TGFβ signaling and cancer stem cell-related gene expression in hepatocellular carcinoma
Xanthine dehydrogenase (XDH), a rate-limiting enzyme involved in purine metabolism, has an essential role in inflammatory cascades. Researchers have known for decades that XDH activity is decreased in some can...
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Article
Phase transformations in Ti–34Al–13Nb alloy
The microstructure and orientation relationship (OR) of the α2 and ωo phases in the Ti–34Al–13Nb (at. %) alloy were investigated. The α2 segments nucleated at the ωo boundaries after aging at 900 °C for 2 h. The ...
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Article
Open AccessAssociation between nutritional risk and routine clinical laboratory measurements and adverse outcomes: a prospective study in hospitalized patients of wuhan tongji hospital
Nutritional risk screening (NRS-2002) and routine clinical laboratory measurements (RCLMs) had been shown to have a predictive value in adverse outcomes in some studies, respectively. This study analyzed the a...
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Article
Open AccessDEGS2 polymorphism associated with cognition in schizophrenia is associated with gene expression in brain
A genome-wide association study of cognitive deficits in patients with schizophrenia in Japan found association with a missense genetic variant (rs7157599, Asn8Ser) in the delta(4)-desaturase, sphingolipid 2 (DEG...
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Article
Open AccessNifuroxazide induces apoptosis and impairs pulmonary metastasis in breast cancer model
Breast carcinoma is the most common female cancer with considerable metastatic potential. Signal transducers and activators of the transcription 3 (Stat3) signaling pathway is constitutively activated in many ...
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Article
Contrasting changes in DRD1 and DRD2 splice variant expression in schizophrenia and affective disorders, and associations with SNPs in postmortem brain
Dopamine 2 receptor (DRD2) is of major interest to the pathophysiology of schizophrenia (SCZ) both as a target for antipsychotic drug action as well as a SCZ-associated risk gene. The dopamine 1 receptor (DRD1...
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Article
Revisiting DARPP-32 in postmortem human brain: changes in schizophrenia and bipolar disorder and genetic associations with t-DARPP-32 expression
Dopamine- and cAMP-regulated phosphoprotein of molecular weight 32 kDa (DARPP-32 or PPP1R1B) has been of interest in schizophrenia owing to its critical function in integrating dopaminergic and glutaminergic sign...
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Article
Open AccessExposure to bisphenol A induces dysfunction of insulin secretion and apoptosis through the damage of mitochondria in rat insulinoma (INS-1) cells
Bisphenol A (BPA) is widely used in plastic products, through which humans are exposed to it. Accumulating evidence suggests that BPA exposure is associated with β-cell dysfunction. Mitochondrial defects can caus...
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Article
Transcription factor TEAD4 regulates expression of Myogenin and the unfolded protein response genes during C2C12 cell differentiation
The TEAD (1–4) transcription factors comprise the conserved TEA/ATTS DNA-binding domain recognising the MCAT element in the promoters of muscle-specific genes. Despite extensive genetic analysis, the function ...
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Article
Open AccessInteractions of human truncated DISC1 proteins: implications for schizophrenia
Numerous genetic linkage and association reports have implicated the Disrupted-in-Schizophrenia (DISC1) gene in psychiatric illness. The Scottish family translocation, predicted to encode a C-terminus-truncated p...
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Article
Essential role of microphthalmia transcription factor for DNA replication, mitosis and genomic stability in melanoma
Malignant melanoma is an aggressive cancer known for its notorious resistance to most current therapies. The basic helix-loop-helix microphthalmia transcription factor (MITF) is the master regulator determinin...
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Article
2D and 3D electrically switchable hexagonal photonic crystal in the ultraviolet range
Two holographic lithography systems are demonstrated for easy and large-area fabrication of 2D and 3D photonic crystal (PhC) microstructures in a polymer dispersed liquid crystal (PDLC) by applying a single to...
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Article
Tumor-specific therapeutic effect induced by an oncolytic adenoviral vector containing heat shock protein 70 and prodrug activation genes
We constructed a melanoma-specific oncolytic adenoviral vector Ad.MCDIRESE1.71Hsp3, in which the cytosine deaminase and adenoviral E1A genes linked by the IRES sequence were under the control of a mouse tyrosinas...
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Article
Engineering conditionally replication-competent adenoviral vectors carrying the cytosine deaminase gene increases the infectivity and therapeutic effect for breast cancer gene therapy
We constructed a conditionally replication-competent adenoviral vector Ad.Lp-CD-IRES-E1A(control) in which the expression of both the prodrug-activating cytosine deaminase gene and the viral replication E1A ge...
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Chapter and Conference Paper
Two-photon absorption imaging with shaped femtosecond laser pulses
Femtosecond laser pulse sha** permits background-free detection of two-photon absorption, which tends to refill spectral holes. This opens up new spectroscopic windows for monitoring tissue characteristics.
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Article
Non-Isomerizable Artificial Pigments: Implications for the Primary Light-Induced Events in Bacteriorhodopsin
The primary events in the photosynthetic retinal protein bacteriorhodopsin (bR) are reviewed in light of photophysical and photochemical experiments with artificial bR in which the native retinal polyene is re...
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Article
Studies on fluorescent species of spiro-indolinonaphthooxazines and their fluorescence spectra
Photophysical behavior of spiro[1,3,3-trimethylindolino-2,3′-naphtho[2,1-b]-1,4-oxazine] (SP1) and spiro[1,3,3,2′-tetramethylindolino-2,3′-naphtho[2,1-b]-1,4-oxazine] (SP2) were studied. The fluorescent species a...
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Chapter
Galactic Fine Structure at 843 MHZ
The Southern Galactic Plane surveyed by the Molonglo Observatory Synthesis Telescope (MOST) gives an unprecedented view of fine-scale structure in low frequency radio continuum emission over the area 245° ≤ l ≤ 3...
