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Open AccessComputerized Cognitive Training in Mild Cognitive Impairment: Findings in African Americans and Caucasians
African Americans with MCI may be at increased risk for dementia compared to Caucasians. The effect of race on the efficacy of cognitive training in MCI is unclear.
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Article
Expectancy Does Not Predict 18-month Treatment Outcomes with Cognitive Training in Mild Cognitive Impairment
Computerized cognitive training (CCT) has emerged as a potential treatment option for mild cognitive impairment (MCI). It remains unclear whether CCT’s effect is driven in part by expectancy of improvement.
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Article
Development of an UPSA Short Form for Use in Longitudinal Studies in the Early Alzheimer’s Disease Spectrum
In individuals with only mild or very mild cognitive attenuations (i.e., so-called pre-clinical AD), performance-based measures of function may be superior to informant-based measures because of increased sens...
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Article
APOE2 enhances neuroprotection against Alzheimer’s disease through multiple molecular mechanisms
The common APOE2 gene variant is neuroprotective against Alzheimer’s disease (AD) and reduces risk by nearly 50%. However, the mechanisms by which APOE2 confers neuroprotection are largely unknown. Here we sho...
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Molecular signatures in post-mortem brain tissue of younger individuals at high risk for Alzheimer's disease as based on APOE genotype
Alzheimer's disease (AD) is a neurodegenerative condition characterized histopathologically by neuritic plaques and neurofibrillary tangles. The objective of this transcriptional profiling study was to identif...
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Erratum: BNDF modulates normal human hippocampal ageing
Correction to Mol Psychiatry 15: 116–118; doi:10.1038/mp.2009.64 After the publication of this article, the authors noticed that the article title and title of the supplementary files were incorrect. The corre...
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BNDF modulates normal human hippocampal ageing
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Genetic variation in MAOA modulates ventromedial prefrontal circuitry mediating individual differences in human personality
Little is known about neural mechanisms underlying human personality and temperament, despite their considerable importance as highly heritable risk mediators for somatic and psychiatric disorders. To identify...
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Article
Allelic variation in GAD1 (GAD67) is associated with schizophrenia and influences cortical function and gene expression
Cortical GABAergic dysfunction has been implicated as a key component of the pathophysiology of schizophrenia and decreased expression of the gamma-aminobutyric acid (GABA) synthetic enzyme glutamic acid decar...
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Neuropsychology of Schizophrenia
Schizophrenia is a debilitating neuropsychiatrie disorder which can result in variable behavioral symptomatology, including hallucinations, delusions, and flat affect. Additionally, schizophrenia has been char...
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Neuropsychologie der Schizophrenie
Schizophrenie ist eine schwere neuropsychiatrische Störung, die zu unterschiedlichen verhaltensmäßigen Symptomen, wie Halluzinationen, Wahnvorstellungen und eingeschränktem Affektausdruck, führen kann. Darüber...