32 Result(s)

Article

Ausbildung

C. Lott, F. Carmona, P. Van de Voorde, A. Lockey, A. Kuzovlev… in Notfall + Rettungsmedizin (2020)

Article

Exploring the relationship between α-actinin-3 deficiency and obesity in mice and humans

Obesity is a worldwide health crisis, and the identification of genetic modifiers of weight gain is crucial in understanding this complex disorder. A common null polymorphism in the fast fiber-specific gene ACTN3

P J Houweling, Y D Berman, N Turner, K G R Quinlan… in International Journal of Obesity (2017)

Article

Disparate metabolic response to fructose feeding between different mouse strains

Diets enriched in fructose (FR) increase lipogenesis in the liver, leading to hepatic lipid accumulation and the development of insulin resistance. Previously, we have shown that in contrast to other mouse str...

M. K. Montgomery, C. E. Fiveash, J. P. Braude, B. Osborne… in Scientific Reports (2015)

Article

Variation in the Williams syndrome GTF2I gene and anxiety proneness interactively affect prefrontal cortical response to aversive stimuli

Characterizing the molecular mechanisms underlying the heritability of complex behavioral traits such as human anxiety remains a challenging endeavor for behavioral neuroscience. Copy-number variation (CNV) in...

M Jabbi, Q Chen, N Turner, P Kohn, M White, J S Kippenhan… in Translational Psychiatry (2015)

Article

A novel chemical uncoupler ameliorates obesity and related phenotypes in mice with diet-induced obesity by modulating energy expenditure and food intake

Decreasing mitochondrial coupling efficiency has been shown to be an effective therapy for obesity and related metabolic symptoms. Here we identified a novel mitochondrial uncoupler that promoted uncoupled res...

Y.-Y. Fu, M. Zhang, N. Turner, L.-N. Zhang, T.-C. Dong, M. Gu, S. J. Leslie… in Diabetologia (2013)

Article

Distinct patterns of tissue-specific lipid accumulation during the induction of insulin resistance in mice by high-fat feeding

While it is well known that diet-induced obesity causes insulin resistance, the precise mechanisms underpinning the initiation of insulin resistance are unclear. To determine factors that may cause insulin res...

N. Turner, G. M. Kowalski, S. J. Leslie, S. Risis, C. Yang, R. S. Lee-Young… in Diabetologia (2013)

Article

Mouse strain-dependent variation in obesity and glucose homeostasis in response to high-fat feeding

Metabolic disorders are commonly investigated using knockout and transgenic mouse models. A variety of mouse strains have been used for this purpose. However, mouse strains can differ in their inherent propens...

M. K. Montgomery, N. L. Hallahan, S. H. Brown, M. Liu, T. W. Mitchell… in Diabetologia (2013)

Article

Assessment of the contribution of the IHC4+C score to decision making in clinical practice in early breast cancer

The immunohistochemical (IHC) 4+C score is a cost-effective prognostic tool that uses clinicopathologic factors and four standard IHC assays: oestrogen receptor (ER), PR, HER2 and Ki67. We assessed its utility...

S Barton, L Zabaglo, R A'Hern, N Turner, T Ferguson, S O'Neill… in British Journal of Cancer (2012)

Article

Amelioration of lipid-induced insulin resistance in rat skeletal muscle by overexpression of Pgc-1β involves reductions in long-chain acyl-CoA levels and oxidative stress

To determine if acute overexpression of peroxisome proliferator-activated receptor, gamma, coactivator 1 beta (Pgc-1β [also known as Ppargc1b]) in skeletal muscle improves insulin action in a rodent model of diet...

L. E. Wright, A. E. Brandon, A. J. Hoy, G.-B. Forsberg, C. J. Lelliott… in Diabetologia (2011)

Article

Time-dependent effects of Prkce deletion on glucose homeostasis and hepatic lipid metabolism on dietary lipid oversupply in mice

We examined the time-dependent effects of deletion of the gene encoding protein kinase C epsilon (Prkce) on glucose homeostasis, insulin secretion and hepatic lipid metabolism in fat-fed mice.

K. Raddatz, N. Turner, G. Frangioudakis, B. M. Liao, D. J. Pedersen… in Diabetologia (2011)

Article

Erratum to: Expression analysis of loci associated with type 2 diabetes in human tissues

C. Cotsapas, L. Prokunina-Olsson, C. Welch, R. Saxena, C. Weaver, N. Usher… in Diabetologia (2011)

Article

Expression analysis of loci associated with type 2 diabetes in human tissues

Genetic map** has identified over 20 loci contributing to genetic risk of type 2 diabetes. The next step is to identify the genes and mechanisms regulating the contributions of genetic risk to disease. The g...

C. Cotsapas, L. Prokunina-Olsson, C. Welch, R. Saxena, C. Weaver, N. Usher… in Diabetologia (2010)

Article

Overexpression of the orphan receptor Nur77 alters glucose metabolism in rat muscle cells and rat muscle in vivo

A hallmark feature of the metabolic syndrome is abnormal glucose metabolism which can be improved by exercise. Recently the orphan nuclear receptor subfamily 4, group A, member 1 (NUR77) was found to be induce...

T. Kanzleiter, E. Preston, D. Wilks, B. Ho, A. Benrick, J. Reznick… in Diabetologia (2010)