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    COMT genotype predicts cortical-limbic D1 receptor availability measured with [11C]NNC112 and PET

    A common polymorphism (val158met) in the gene encoding catechol-O-methyltransferase (COMT) has been shown to affect dopamine (DA) tone in cortex and cortical functioning. D1 receptors are the main DA receptors in...

    M Slifstein, B Kolachana, E H Simpson, P Tabares, B Cheng, M Duvall… in Molecular Psychiatry (2008)