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Article
Synthesis of fluoride-releasing carbonate apatites for bone substitutes
Fluoride (F−)-substituted B-type carbonate hydroxyapatite (CHAP) powders were prepared for application as bone substitute materials having the ability to enhance bone formation and to suppress bone resorption due...
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Article
Biomimetic coating of an apatite layer on poly(l-lactic acid); improvement of adhesive strength of the coating
A biodegradable polymer coated with a bonelike apatite layer on its surface would be useful as a scaffold for bone tissue regeneration. In this study, poly(l-lactic acid) (PLLA) was treated with oxygen plasma to ...
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Article
Calcium phosphate coating formed in infusion fluid mixture to enhance fixation strength of titanium screws
A novel technique was developed to coat a calcium phosphate (CaP) layer on titanium screws with a titanium oxide surface layer, using infusion fluids officially approved for clinical use. A calcium-containing ...
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Article
Open AccessBMP-2 gene-fibronectin-apatite composite layer enhances bone formation
Safe and efficient gene transfer systems are needed for tissue engineering. We have developed an apatite composite layer including the bone morphogenetic protein-2 (BMP-2) gene and fibronectin (FB), and we evalua...
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Article
Enhanced wound healing associated with Sharpey’s fiber-like tissue formation around FGF-2-apatite composite layers on percutaneous titanium screws in rabbits
Pin-tract infections are the most common complications of external fixation. To solve the problem, we developed a fibroblast growth factor-2 (FGF-2)-apatite composite layer for coating titanium screws. The pur...
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Article
Fabrication of a DNA-lipid-apatite composite layer for efficient and area-specific gene transfer
A surface-mediated gene transfer system using biocompatible apatite-based composite layers has great potential for tissue engineering. Among the apatite-based composite layers developed to date, we focused on ...
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Article
Open AccessZn- and Mg- Containing Tricalcium Phosphates-Based Adjuvants for Cancer Immunotherapy
Zn- and Mg-containing tricalcium phosphates (TCPs) loaded with a hydrothermal extract of a human tubercle bacillus (HTB) were prepared by immersing Zn-TCP and Mg-TCP in HTB-containing supersaturated calcium ph...
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Article
Open AccessA phase I study on combined therapy with proton-beam radiotherapy and in situ tumor vaccination for locally advanced recurrent hepatocellular carcinoma
Proton-beam radiotherapy (PBT) has been shown to be effective to hepatocellular carcinoma (HCC) as a nonsurgical local treatment option. However, HCC still remains as one of the most difficult cancers to be cu...
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Chapter
Signal Molecule-Calcium Phosphate Composites: Novel Approaches to Controlling Cellular and/or Biological Reactions and Functions
Signal molecule-calcium phosphate (CaP) composites are formed in supersaturated CaP solutions containing signal molecules. The molecules coprecipitate with CaPs in the form of coating layers or particulates an...
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Article
Effects of gatifloxaine content in gatifloxacine-loaded PLGA and β-tricalcium phosphate composites on efficacy in treating osteomyelitis
Composites of gatifloxacin (GFLX)-loaded poly (lactic-co-glycolic) acid (PLGA) and β-tricalcium phosphate (βTCP) containing 0, 1, and 10 wt % GFLX (0, 1, and 10 wt % GFLX composites), and GFLX-loaded PLGA cont...
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Article
Open AccessReducing the risk of impaired bone apposition to titanium screws with the use of fibroblast growth factor-2−apatite composite layer coating
Loosening of screws is a common problem in orthopedic and maxillofacial surgery. Modifying the implant surface to improve the mechanical strength of screws has been tried and reported. We developed screws coat...
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Article
Open AccessHollow boron nitride nanospheres as boron reservoir for prostate cancer treatment
High global incidence of prostate cancer has led to a focus on prevention and treatment strategies to reduce the impact of this disease in public health. Boron compounds are increasingly recognized as preventa...
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Article
Open AccessHierarchically porous, and Cu- and Zn-containing γ-AlOOH mesostrands as adjuvants for cancer immunotherapy
Alum is the only licensed adjuvant by Food and Drug Administration of USA used in many human vaccines and has excellent safety record in clinical applications. However, alum hardly induces T helper 1 (Th1) imm...
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Article
Open AccessA nanoscale metal organic frameworks-based vaccine synergises with PD-1 blockade to potentiate anti-tumour immunity
Checkpoint blockade therapy has provided noteworthy benefits in multiple cancers in recent years; however, its clinical benefits remain confined to 10–40% of patients with extremely high costs. Here, we design...
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Article
Open AccessTotal body irradiation causes a chronic decrease in antioxidant levels
Ionizing radiation exposure may not only cause acute radiation syndrome, but also an increased risk of late effects. It has been hypothesized that induction of chronic oxidative stress mediates the late effect...
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Article
Open AccessBiosafety of mesoporous silica nanoparticles: a combined experimental and literature study
Mesoporous silica (MS) particles have been explored for various healthcare applications, but universal data about their safety and/or toxicity are yet to be well-established for clinical purposes. Information ...
