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Article
Open AccessEffect of immunosuppressants on a mouse model of osteogenesis imperfecta type V harboring a heterozygous Ifitm5 c.-14C > T mutation
Osteogenesis imperfecta (OI) type V is an autosomal dominant disorder caused by the c.-14C > T mutation in the interferon-induced transmembrane protein 5 gene (IFITM5), however, its onset mechanism remains unclea...
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Article
Open AccessNon-invasive Photodynamic Therapy in Brain Cancer by Use of Tb3+-Doped LaF3 Nanoparticles in Combination with Photosensitizer Through X-ray Irradiation: A Proof-of-Concept Study
The use of photodynamic therapy (PDT) in the treatment of brain cancer has produced exciting results in clinical trials over the past decade. PDT is based on the concept that a photosensitizer exposed to a spe...
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Article
Open AccessHollow boron nitride nanospheres as boron reservoir for prostate cancer treatment
High global incidence of prostate cancer has led to a focus on prevention and treatment strategies to reduce the impact of this disease in public health. Boron compounds are increasingly recognized as preventa...
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Article
IFITM5 mutations and osteogenesis imperfecta
Interferon-induced transmembrane protein 5 (IFITM5) is an osteoblast-specific membrane protein that has been shown to be a positive regulatory factor for mineralization in vitro. However, Ifitm5 knockout mice do ...
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Biomedical Applications of Sol-Gel Nanocomposites
This chapter introduces nanocomposites of silica, titania, calcium phosphates, biologically active glasses, and their polymer-modified derivatives with meso- and macro-porous, nanotubular, or hollow nanopartic...
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Article
Open AccessBinding Mode of CpG Oligodeoxynucleotides to Nanoparticles Regulates Bifurcated Cytokine induction via Toll-like Receptor 9
The interaction of cytosine-phosphate-guanine oligodeoxynucleotides (CpG ODNs) with Toll-like receptor 9 (TLR9) activates the immune system. Multimeric class A CpG ODNs induce interferon-α (IFN-α) and, to a le...
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Article
Open AccessNm23/nucleoside diphosphate kinase-A as a potent prognostic marker in invasive pancreatic ductal carcinoma identified by proteomic analysis of laser micro-dissected formalin-fixed paraffin-embedded tissue
Pancreatic cancer is among the most lethal malignancies worldwide. This study aimed to identify a novel prognostic biomarker, facilitating treatment selection, using mass spectrometry (MS)-based proteomic anal...
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Article
Open AccessFormation of Nano-Bio-Complex as Nanomaterials Dispersed in a Biological Solution for Understanding Nanobiological Interactions
Information on how cells interface with nanomaterials in biological environments has important implications for the practice of nanomedicine and safety consideration of nanomaterials. However, our current unde...
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Article
Open AccessGenotoxicity and molecular response of silver nanoparticle (NP)-based hydrogel
Since silver-nanoparticles (NPs) possess an antibacterial activity, they were commonly used in medical products and devices, food storage materials, cosmetics, various health care products, and industrial prod...
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Article
Open AccessNuclease-resistant immunostimulatory phosphodiester CpG oligodeoxynucleotides as human Toll-like receptor 9 agonists
Unmethylated cytosine-guanine (CpG) motif-containing oligodeoxynucleotides (ODNs) have been well characterized as agonists of Toll-like receptor 9 (TLR9). ODNs with a phosphorothioate (PTO) backbone have been ...
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Article
Transfection efficiency for size-separated cells synchronized in cell cycle by microfluidic device
Non-viral system generally demonstrates less efficacious in transgene delivery than viral system; however it represents a safer alternative to viral system. In this study, transfection efficiency for human hep...
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Article
Characterization of the osteoblast-specific transmembrane protein IFITM5 and analysis of IFITM5-deficient mice
Interferon-inducible transmembrane protein 5 (IFITM5) is an osteoblast-specific membrane protein whose expression peaks around the early mineralization stage during the osteoblast maturation process. To invest...
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Article
Crystal structure refinement of A-type carbonate apatite by X-ray powder diffraction
Complete carbonate substitution at A-sites (OH) of low-crystallinity hydroxyapatite with near stoichiometric composition (i.e. Ca/P ratio of 1.65) was achieved by heating in a dry carbon dioxide flow at 1173 K...
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Article
Scavenger receptor B2 is a cellular receptor for enterovirus 71
Enterovirus 71 (EV71) causes hand, foot and mouth disease, a mild infectious disease that can, however, occasionally lead to severe neurological impairments. These two studies, by Nishimura et al. and Yamayoshi e...
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Article
Fructose-2,6-bisphosphate contents were increased in response to salt, water and osmotic stress in leaves of Bruguiera gymnorrhiza by differential changes in the activity of the bifunctional enzyme 6-phosphofructo-2-kinase/fructose-2,6-bisphosphate 2-phosphatase
The steady-state level of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphate 2-phosphatase (F6P2K/F26BPase) transcript has been found to be raised in the mangrove Bruguiera gymnorrhiza treated with 500 mM NaCl fo...
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Article
Molecular cloning and characterization of genes encoding BURP domain-containing protein in the mangrove, Bruguiera gymnorrhiza
We cloned and characterized four independent genes encoding BURP domain-containing proteins from mangrove, Bruguiera gymnorrhiza, two as cDNA (BgBDC2 and BgBDC3) and the other two as genomic DNA (S2 and L3). The...
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Article
Molecular characterization and response to salt stress of mRNAs encoding cytosolic Cu/Zn superoxide dismutase and catalase from Bruguiera gymnorrhiza
To analyze the potential of the active oxygen-scavenging system of the cytosol in leaves of salt-stressed Bruguiera gymnorrhiza, we isolated a full-length cDNA encoding a 153-amino-acid sequence of cytosolic Cu/...
