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  1. Article

    Open Access

    Potential of Gold Nanoparticles for Noninvasive Imaging and Therapy for Vascular Inflammation

    Macrophages contribute to the progression of vascular inflammation, making them useful targets for imaging and treatment of vascular diseases. Gold nanoparticles (GNPs) are useful as computed tomography (CT) c...

    Hisanori Kosuge, Maki Nakamura, Ayako Oyane, Kazuko Tajiri… in Molecular Imaging and Biology (2022)

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  2. No Access

    Chapter

    Synthesis of Calcium-Phosphate-Based Nanoparticles as Biocompatible and Biofunctional Element Blocks

    Calcium phosphate (CaP)-based nanoparticles containing functional substances such as DNA and Ag are biocompatible and biofunctional element blocks that are useful as agents for drug and gene delivery and as bu...

    Ayako Oyane, Maki Nakamura in New Polymeric Materials Based on Element-Blocks (2019)

  3. No Access

    Chapter

    Signal Molecule-Calcium Phosphate Composites: Novel Approaches to Controlling Cellular and/or Biological Reactions and Functions

    Signal molecule-calcium phosphate (CaP) composites are formed in supersaturated CaP solutions containing signal molecules. The molecules coprecipitate with CaPs in the form of coating layers or particulates an...

    **upeng Wang, Ayako Oyane, Atsuo Ito in Advances in Calcium Phosphate Biomaterials (2014)

  4. No Access

    Article

    Fabrication of a DNA-lipid-apatite composite layer for efficient and area-specific gene transfer

    A surface-mediated gene transfer system using biocompatible apatite-based composite layers has great potential for tissue engineering. Among the apatite-based composite layers developed to date, we focused on ...

    Ayako Oyane, Yushin Yazaki, Hiroko Araki… in Journal of Materials Science: Materials in… (2012)

  5. No Access

    Article

    Enhanced wound healing associated with Sharpey’s fiber-like tissue formation around FGF-2-apatite composite layers on percutaneous titanium screws in rabbits

    Pin-tract infections are the most common complications of external fixation. To solve the problem, we developed a fibroblast growth factor-2 (FGF-2)-apatite composite layer for coating titanium screws. The pur...

    Hirotaka Mutsuzaki, Atsuo Ito, Yu Sogo… in Archives of Orthopaedic and Trauma Surgery (2012)

  6. Article

    Open Access

    BMP-2 gene-fibronectin-apatite composite layer enhances bone formation

    Safe and efficient gene transfer systems are needed for tissue engineering. We have developed an apatite composite layer including the bone morphogenetic protein-2 (BMP-2) gene and fibronectin (FB), and we evalua...

    Wei Zhang, Hideo Tsurushima, Ayako Oyane, Yushin Yazaki… in Journal of Biomedical Science (2011)

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  7. No Access

    Article

    Biomimetic coating of an apatite layer on poly(l-lactic acid); improvement of adhesive strength of the coating

    A biodegradable polymer coated with a bonelike apatite layer on its surface would be useful as a scaffold for bone tissue regeneration. In this study, poly(l-lactic acid) (PLLA) was treated with oxygen plasma to ...

    Yoshiro Yokoyama, Ayako Oyane, Atsuo Ito in Journal of Materials Science: Materials in… (2007)

  8. No Access

    Article

    Calcium phosphate coating formed in infusion fluid mixture to enhance fixation strength of titanium screws

    A novel technique was developed to coat a calcium phosphate (CaP) layer on titanium screws with a titanium oxide surface layer, using infusion fluids officially approved for clinical use. A calcium-containing ...

    Hirotaka Mutsuzaki, Atsuo Ito… in Journal of Materials Science: Materials in… (2007)