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Synthesis of fluoride-releasing carbonate apatites for bone substitutes

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Abstract

Fluoride (F−)-substituted B-type carbonate hydroxyapatite (CHAP) powders were prepared for application as bone substitute materials having the ability to enhance bone formation and to suppress bone resorption due to the therapeutic effect of F−. F− was adsorbed on CHAP in a sodium fluoride solution followed by heating at 700°C in carbon dioxide flow to substitute F− for the hydroxyl ion in the CHAP structure. The F− contents in the F-substituted CHAP powders were 16–22 times greater than that in normal adult human bones. The carbonate ion contents in the F-substituted CHAP powders corresponded to or were higher than that in normal adult human bones. F-substituted CHAP powder with CO 2−3 and F− contents of 11.03 and 0.66 wt%, respectively, slowly released F− in a physiological salt solution to a sufficiently high F− level. The F− concentration slowly increased and reached 67.20 ± 4.81 μg l−1, which was 1.5–9.3 times higher than that in the body fluid of normal adult humans, near the therapeutic window of F−, and far lower than the estimated toxic level. Therefore, the F-substituted CHAP can promote bone formation. The present F-substituted CHAP has the advantage of slow F− release over sodium fluoride and sodium monofluorophosphate which are highly soluble salts and cannot be sintered into a ceramic body.

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Acknowledgement

This study was supported in part by research grant No. EB003070 (PI: RZ LeGeros) from the NIBIB/NIH.

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Authors and Affiliations

  1. Institute for Human Science and Biomedical Engineering, National Institute of Advanced Industrial Science and Technology, Central 6, 1-1-1 Higashi, Tsukuba-shi, Ibaraki, 305-8566, Japan

    Yu Sogo & Atsuo Ito

  2. Department of Resources and Environmental Engineering, School of Science and Engineering, Waseda University, 3-4-1 Okubo, Shinjuku-ku, Tokyo, 169-8555, Japan

    Daiki Yokoyama & Atsushi Yamazaki

  3. Department of Biomaterials, College of Dentistry, New York University, 345 East 24th St (Room 806), New York, NY, 10010, USA

    Racquel Z. LeGeros

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  1. Yu Sogo
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  2. Atsuo Ito
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  4. Atsushi Yamazaki
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  5. Racquel Z. LeGeros
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Correspondence to Yu Sogo.

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Sogo, Y., Ito, A., Yokoyama, D. et al. Synthesis of fluoride-releasing carbonate apatites for bone substitutes. J Mater Sci: Mater Med 18, 1001–1007 (2007). https://doi.org/10.1007/s10856-006-0092-z

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