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Article
Open AccessDecentralized Learning with Virtual Patients for Medical Diagnosis of Diabetes
Machine learning, applied to medical data, can uncover new knowledge and support medical practices. However, analyzing medical data by machine learning methods presents a trade-off between accuracy and privacy...
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Article
Focusing on delayed clearance for identifying small-sized metastatic lung tumors using synchrotron radiation angiography with a highly sensitive receiver
To detect metastatic lung tumors of less than 1 mm in size by focusing on the clearance of contrast material using synchrotron radiation (SR) angiography characterized by high spatial resolution and high-sensi...
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Article
Fabrication of a DNA-lipid-apatite composite layer for efficient and area-specific gene transfer
A surface-mediated gene transfer system using biocompatible apatite-based composite layers has great potential for tissue engineering. Among the apatite-based composite layers developed to date, we focused on ...
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Article
Open AccessBMP-2 gene-fibronectin-apatite composite layer enhances bone formation
Safe and efficient gene transfer systems are needed for tissue engineering. We have developed an apatite composite layer including the bone morphogenetic protein-2 (BMP-2) gene and fibronectin (FB), and we evalua...
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Chapter
Malignant Brain Tumors: Role of Radioresponsive Gene Therapy
Patients with malignant gliomas have a very poor prognosis. To explore a novel and more effective approach for the treatment of malignant gliomas, a strategy combining suicide gene therapy and radiation treatm...
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Article
Targeted Tumor Cell Death Induced by Autologous Tumor-Specific T Lymphocyte Recognition of Wild-Type p53-Derived Peptides
Autologous tumor-specific T lymphocyte (ATTL) lines were derived from the peripheral blood mononuclear cells (PBMC) of a healthy volunteer with human leukocyte antigen (HLA) -A*0201. These lines were achieved ...
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Article
Recycled addition of CD4+ T cell-rich population for induction of human autologous cytotoxic T lymphocytes: A practically efficient method
When CD4+ T cell-rich population appears in theinitial trial in induction cultures of humanautologous cytotoxic T lymphocytes (CTL), the cultureresults frequently in no or weak killing activity andtherefore usual...
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Article
Expansion of human autologous cytotoxic T lymphocytes on fixed target tumor cells
Human tumor specific cytotoxic T lymphocytes (CTL) were expanded on formalin-fixed autologous target tumor cells derived from glioblastoma multiforme. Growth response of the CTL restimulated with the fixed tar...
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Article
MRI of an infant with Fisher syndrome
A 15-month-old female infant with nystagmus, gait disturbance, diminished reflexes, ophthalmoplegia, and facial paresis was diagnosed as having Fisher syndrome. Magnetic resonance imaging revealed a transient...
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Chapter and Conference Paper
Stemline Study Based on the Nuclear Characterization and Image Cytometry in Resected Brain Tumors
We examined nuclear morphometry and DNA content in SG2M phase tumor cells by using image analysis in relation to time to tumor progression (TTP) in 73 brain tumor patients from whom clinical follow-up was obta...
