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  1. No Access

    Article

    Structural basis for recognition of centromere histone variant CenH3 by the chaperone Scm3

    Centromeres, regions on the chromosome that are essential for accurate chromosome segregation, contain unique chromatin that is marked by a histone H3 variant termed CenH3 or CENP-A. The simple centromeres of ...

    Zheng Zhou, Hanqiao Feng, Bing-Rui Zhou, Rodolfo Ghirlando, Kaifeng Hu… in Nature (2011)

  2. No Access

    Article

    CARMIL leading edge localization depends on a non-canonical PH domain and dimerization

    CARMIL is an approximately 1,370-amino-acid cytoskeletal scaffold that has crucial roles in cell motility and tissue development through interactions with cytoskeletal effectors and regulation of cap** prote...

    Adam Zwolak, Changsong Yang, Elizabeth A. Feeser, E. Michael Ostap… in Nature Communications (2013)

  3. No Access

    Article

    Cap** protein regulators fine-tune actin assembly dynamics

  4. Cap** protein (CP) is a major regulator of actin assembly dynamics via the cap** of actin filament barbed ends. The cap** activity of CP can be regulated...

    5. Marc Edwards, Adam Zwolak, Dorothy A. Schafer… in Nature Reviews Molecular Cell Biology (2014)

  5. Article

    Erratum: Cap** protein regulators fine-tune actin assembly dynamics

    Nature Reviews Molecular Cell Biology 15, 677–689 (2014) On page 684 of the above article, there was a mistake in Figure 3b: the PH domain of CARMIL preferentially binds to monophosphorylated membrane lipids r...

    Marc Edwards, Adam Zwolak, Dorothy A. Schafer… in Nature Reviews Molecular Cell Biology (2014)

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  6. Article

    Open Access

    Rapid Purification of Human Bispecific Antibodies via Selective Modulation of Protein A Binding

    Methods to rapidly generate high quality bispecific antibodies (BsAb) having normal half-lives are critical for therapeutic programs. Here, we identify 3 mutations (T307P, L309Q, and Q311R or “TLQ”) in the Fc ...

    Adam Zwolak, Catherine N. Leettola, Susan H. Tam, Dennis R. Goulet… in Scientific Reports (2017)

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  7. Article

    Open Access

    High-Throughput Generation of Bipod (Fab × scFv) Bispecific Antibodies Exploits Differential Chain Expression and Affinity Capture

    Generation of bispecific antibodies (BsAbs) having two unique Fab domains requires heterodimerization of the two heavy chains and pairing of each heavy chain with its cognate light chain. An alternative bispec...

    Thomas C. Nesspor, Kyle Kinealy, Nicholas Mazzanti, Michael D. Diem… in Scientific Reports (2020)

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  8. Article

    Open Access

    A stable, engineered TL1A ligand co-stimulates T cells via specific binding to DR3

    TL1A (TNFSF15) is a TNF superfamily ligand which can bind the TNFRSF member death receptor 3 (DR3) on T cells and the soluble decoy receptor DcR3. Engagement of DR3 on CD4+ or CD8+ effector T cells by TL1A ind...

    Adam Zwolak, Szeman Ruby Chan, Paul Harvilla, Sally Mahady… in Scientific Reports (2022)

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