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  1. Article

    Open Access

    High-Throughput Generation of Bipod (Fab × scFv) Bispecific Antibodies Exploits Differential Chain Expression and Affinity Capture

    Generation of bispecific antibodies (BsAbs) having two unique Fab domains requires heterodimerization of the two heavy chains and pairing of each heavy chain with its cognate light chain. An alternative bispec...

    Thomas C. Nesspor, Kyle Kinealy, Nicholas Mazzanti, Michael D. Diem… in Scientific Reports (2020)

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  2. Article

    Open Access

    Specific Y14 domains mediate its nucleo-cytoplasmic shuttling and association with spliced mRNA

    Pre-mRNA splicing deposits multi-protein complexes, termed exon junction complexes (EJCs), on mRNAs near exon-exon junctions. The core of EJC consists of four proteins, eIF4AIII, MLN51, Y14 and Magoh. Y14 is a...

    Naoyuki Kataoka, Michael D. Diem, Mayumi Yoshida, Chihiro Hatai… in Scientific Reports (2011)

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  3. No Access

    Article

    PYM binds the cytoplasmic exon-junction complex and ribosomes to enhance translation of spliced mRNAs

    Messenger RNAs produced by splicing are translated more efficiently than those produced from similar intronless precursor mRNAs (pre-mRNAs). The exon-junction complex (EJC) probably mediates this enhancement; ...

    Michael D Diem, Chia C Chan, Ihab Younis… in Nature Structural & Molecular Biology (2007)