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Article

A stable, engineered TL1A ligand co-stimulates T cells via specific binding to DR3

TL1A (TNFSF15) is a TNF superfamily ligand which can bind the TNFRSF member death receptor 3 (DR3) on T cells and the soluble decoy receptor DcR3. Engagement of DR3 on CD4+ or CD8+ effector T cells by TL1A ind...

Adam Zwolak, Szeman Ruby Chan, Paul Harvilla, Sally Mahady… in Scientific Reports (2022)