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  1. Article

    Open Access

    Rapid Purification of Human Bispecific Antibodies via Selective Modulation of Protein A Binding

    Methods to rapidly generate high quality bispecific antibodies (BsAb) having normal half-lives are critical for therapeutic programs. Here, we identify 3 mutations (T307P, L309Q, and Q311R or “TLQ”) in the Fc ...

    Adam Zwolak, Catherine N. Leettola, Susan H. Tam, Dennis R. Goulet… in Scientific Reports (2017)

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  2. Article

    Open Access

    Characterization of the SAM domain of the PKD-related protein ANKS6 and its interaction with ANKS3

    Autosomal dominant polycystic kidney disease (ADPKD) is the most common genetic disorder leading to end-stage renal failure in humans. In the PKD/Mhm(cy/+) rat model of ADPKD, the point mutation R823W in the s...

    Catherine N Leettola, Mary Jane Knight, Duilio Cascio… in BMC Structural Biology (2014)

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