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Open AccessA stable, engineered TL1A ligand co-stimulates T cells via specific binding to DR3
TL1A (TNFSF15) is a TNF superfamily ligand which can bind the TNFRSF member death receptor 3 (DR3) on T cells and the soluble decoy receptor DcR3. Engagement of DR3 on CD4+ or CD8+ effector T cells by TL1A ind...
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Open AccessSTAT1-deficient mice spontaneously develop estrogen receptor α-positive luminal mammary carcinomas
Although breast cancers expressing estrogen receptor-α (ERα) and progesterone receptors (PR) are the most common form of mammary malignancy in humans, it has been difficult to develop a suitable mouse model sh...
