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Article
Effect of retinol on interaction of the protein period1, oxytocin, and GABA at the prenatal period of formation of the circadian clock-mechanism in rats
In mammals, clock-gene proteins are expressed in the neurons of hypot halamic suprachiasmatic nucleus and that of other CNS structures, in the muscles, visceral organs and vessels, thus forming circadian rhyth...
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Article
Participation of agouti-related peptide in the regulation of the wakefulness-sleep cycle
Agouti-related peptide is expressed in the hypothalamic neurons in humans and animals. Immunohistochemical studies in Wistar rats shows significant changes in the optical density of agouti-related peptide in t...
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Article
An Immunohistochemical Study of Cart Peptide in the Striatonigral Projections in Dopamine Deficiency
Studies in Wistar rats identified increases in the optical density of CART peptide both in nucleus accumbens neurons and their processes in the substantia nigra on the background of a 28% reduction in the numb...
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Article
Interaction of the Dopaminergic and Vasopressinergic Systems in Sleep Deprivation in Rats
Rats were subjected to 6-h sleep deprivation and were given three injections of the dopamine D1 receptor blocker SCH 39166. Immunohistochemical investigations revealed increases in D1 and D2 dopamine receptor and...
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Article
Analysis of development of morphophunctional interconnections between CART- and AGRPergic neurons with dopaminergic structures in ontogenesis of mammals
Morphogenesis and, probably, formation of structural-functional interaction between the CART- and dopaminergic neurons in rats were found to occur as early as during embryonic development. Meanwhile, formation...
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Article
The Role of AGRP in Regulating Dopaminergic Neurons in the Brain
Immunoreactive processes containing agouti-regulated protein (AGRP) were detected in various dopaminergic structures in the brains of rats and mice. Double immunolabeling demonstrated the presence of AGRP-immu...
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Article
Localization of the dopamine receptors of types 1 and 2 on the bodies of POMC-expressing neurons of the arcuate nucleus of the hypothalamus in mice and rats
Using immunofluorescent techniques, we have demonstrated the presence of two main types of dopamine receptors, D1 and D2, on the bodies of neurons of the arcuate nucleus of the hypothalamus expressing the prec...
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Article
Metabolic parameters and functional state of hypothalamic signaling systems in AY/a mice with genetic predisposition to obesity and the effect of metformin
The metabolic parameters and functional state of hypothalamic systems in mice with the Yellow mutation in the Agouti locus and with obesity of the melanocortin type and the effect of metformin (MF) treatment (...
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Article
Immunohistochemical Evidence for the Localization of Dopamine Receptors on Neuropeptide Y-Expressing Neurons in Rat Arcuate Nuclei
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Article
An Immunohistochemical Study of the Pathways of the Influence of Dopamine on Orexinergic Neurons in the Perifornical Area of the Hypothalamus
Confocal microscopy was used to analyze double immunolabeling and provided evidence of the locations of a large number of tyrosine hydroxylase-immunopositive processes around the bodies of orexinergic neurons ...
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Article
Effects of Active Fragments AgRP 83-132 and 25-51 on Dopamine Biosynthesis in the Brain
Experiments using C57BL/6J mice 3 h after administration of agouti gene-related peptide (AgRP) fragments 83-132 and 25-51 into the midbrain identified dose-dependent inhibitory effects on dopaminergic neurons....
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Article
The Role of the AgRP 25-51 Active Fragment in the Regulation of Functional Activity of Locus Coeruleus Norepinephrinergic Neurons and in Norepinephrine Biosynthesis
Double fluorescence immunolabeling and confocal microscopy showed that the nerve processes immediately surrounding norepinephrinergic (NE) neurons in the brainstem locus coeruleus (LC) are immunopositive to Ag...
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Article
Assessment of Heat-Shock Protein Hsp70 Colocalization with Markers of Tumor Stem-Like Cells
The search of biomarkers for early diagnosis and theranostics of glioblastoma multiforme (GBM) due to the aggressiveness of the disease is an urgent needed. In the present work, the expression of the heat-shoc...
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Article
Analysis of the Hypothalamic Orexinergic System in Rats with Different Forms of Genetically Determined Epilepsy
The hypothalamic orexigenic system was studied in mature males of two rat strains with a genetic predisposition to various forms of epileptic activity: Krushinsky–Molodkina (KM) rats characterized by audiogeni...
