Abstract
Morphogenesis and, probably, formation of structural-functional interaction between the CART- and dopaminergic neurons in rats were found to occur as early as during embryonic development. Meanwhile, formation of the AGRPergic system and its structural-functional connections was observed in the course of postnatal ontogenesis. Analysis of literature and the results of our own investigation show that differentiation of dopaminergic neurons in hypothalamus and midbrain occurs concurrently with development of the CARTergic neurons and in the absence of AGRP. Considering our data on the stimulatory effect of the CART-peptide and the inhibitory effect of AGRP on dopaminergic brain neurons, we believe that the leading component in formation of functional interactions of these systems is the later maturing AGRPergic system.
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Original Russian Text © I.V. Romanova, A.L. Mikhrina, M.P. Chernysheva, 2014, published in Zhurnal Evolyutsionnoi Biokhimii i Fiziologii, 2014, Vol. 50, No. 5, pp. 1392–398.
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Romanova, I.V., Mikhrina, A.L. & Chernysheva, M.P. Analysis of development of morphophunctional interconnections between CART- and AGRPergic neurons with dopaminergic structures in ontogenesis of mammals. J Evol Biochem Phys 50, 448–455 (2014). https://doi.org/10.1134/S0022093014050093
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DOI: https://doi.org/10.1134/S0022093014050093