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Article
Anticonvulsant Efficacy of Inhibition of Synaptic and Extrasynaptic GABA-Transporters in the Prevention of Hyperbaric Oxygen Seizures
Hyperbaric oxygen (HBO2) inhibits GABAergic neurotransmission in the brain, which can lead to the development of seizure disorders known as oxygen epilepsy. HBO2-induced deficiency in GABAergic transmission, resu...
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Article
Reaction of the Hippocampal Microglia to Hyperbaric Oxygen
We studied the reaction of rat hippocampal microgliocytes to hyperbaric oxygen at a pressure of 5 ata (absolute atmosphere). Immunohistochemical analysis with selective macrophage marker CD68 (ED1) and microgl...
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Article
Mechanisms of Physiological and Neurotoxic Action of Hyperbaric Oxygen
During the period of use of hyperbaric oxygen (HBO2) in medical treatment and in scuba diving, extensive knowledge has been accumulated about the mechanisms of its biological action. In the present work, we analy...
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Article
Prenatal Hypoxia Impairs Olfactory Function in Postnatal Ontogeny in Rats
Analysis of the age-related dynamics of olfactory behavior in the odor preference and food search testsshowed that all male Wistar rats, regardless of age, preferred valerian essential oil, whose components ha...
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Article
Involvement of Glutamine Synthetase in the Development of Hyperbaric Oxygen Seizures
Hyperbaric oxygen (HBO2) causes a toxic effect on the central nervous system via poorly understood mechanisms. The aim of this study was to test the hypothesis that HBO2 inhibits the activity of glutamine synthet...
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Article
Changes in Kolmer Cells in SHR Rats after Cerebral Ischemia
Kolmer cells (epiplexus macrophages) constitute the least studied population among the phagocytosing cells in the mammalian brain. We report here studies of the reactions of these cells to ischemic brain injur...
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Article
A Comparison of Microglia Detection in Mammals and Humans Using Purinergic Receptor P2Y12 Labeling
The problem of choosing an adequate method to detect microglia is relevant for modern neurophysiological and interdisciplinary research due to the lack of universal approaches allowing visualization of this ce...
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Article
Inhibition of GABA-Transaminase and GABA-Transporters in the Brain by Vigabatrin and Tiagabine Prevents Seizure Development in Rats Breathing Hyperbaric Oxygen
Hyperbaric oxygen (HBO2) inhibits the GABAergic function in the brain, leading to the development of convulsive reactions in the form of paroxysmal discharges on the EEG, as well as movement disorders, in a manne...
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Article
Blockade of Brain Adrenoreceptors Delays Seizure Development during Hyperbaric Oxygen Breathing
The main prodromal sign of seizures develo** when breathing hyperbaric oxygen is a high activity of sympathetic outflow, as manifested in altered external respiration, impaired cardiac and vascular activity....
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Article
Blockade Of γ-Aminobutyric Acid Transporters In Brain Synapses Protects Against Hyperbaric Oxygen-Induced Convulsions
Respiration of hyperbaric oxygen (HBO2) suppresses the synthesis of γ-aminobutyric acid (GABA) in the brain, leading to weakening of inhibitory GABAergic neurotransmission and the development of convulsive syndro...
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Article
Effects of Active Fragments AgRP 83-132 and 25-51 on Dopamine Biosynthesis in the Brain
Experiments using C57BL/6J mice 3 h after administration of agouti gene-related peptide (AgRP) fragments 83-132 and 25-51 into the midbrain identified dose-dependent inhibitory effects on dopaminergic neurons....
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Article
Adaptive Mechanisms of Baroreflectory Regulation of the Cardiovascular System in Extreme Hyperoxia
The cardiovascular system of vertebrates, including humans, is well known to respond to hyperoxia by vasoconstriction, bradycardia and decreased contractility of the left heart ventricle. We hypothesized that ...
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Article
Microglia of the Brain: Origin, Structure, Functions
The review summarizes data on microglyocytes in the brain of mammals. General characteristics and features of their structure, functions and molecular organization at different ontogenetic stages are addressed...
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Article
Structural Organization of Astrocytes in the Subgranular Zone of the Rabbit Hippocampal Dentate Fascia
Neurogenesis in the subgranular zone (SGZ) of the mammalian hippocampus is well known to occur throughout the life span. Astrocytes in this specialized proliferative zone are supposed to have properties of pro...
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Article
Distribution of polyglutamine proteins in Purkinje cells of the human and rat cerebellum
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Article
Structure and Spatial Organization of Microgliocytes in the Molecular Layer of the Cerebellar Cortex in Rabbits
Immunocytochemical and confocal laser microscopy were used to study the structural organization and spatial distribution of microgliocytes in the molecular layer of the cerebellar cortex in fi ve adult male ra...
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Article
Neuroglobin, an oxygen-binding protein in the mammalian nervous system (localization and putative functions)
The review summarizes current data on neuroglobin, the heme-containing protein discovered in mammalian nerve cells in 2000. It presents general characteristics of neuroglobin as well as data on its evolutionar...
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Article
Intranuclear Accumulation of Iba-1 Protein in Microgliocytes in the Human Brain
Iba-1 protein is a widely recognized marker for microglial cells and was previously observed by the authors in microgliocyte nuclei. The aim of the present work was to refine these data using immunocytochemist...
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Article
Recovery of learning and memory impaired by prenatal hypoxic stress in rats after injection of caspase-3 inhibitor during early ontogenesis
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Article
Intermediate filament proteins in tanycytes of the third cerebral ventricle in rats during postnatal ontogenesis
Cytoskeletal intermediate filaments (IF) are composed of proteins able to form homo- and heterodimers, while their repertoire can change during cell differentiation. Data on the IF protein composition in tanyc...
