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Article
Expression of Pro-Fibrotic Factors in Cardiac Tissue of Wistar and Sprague–Dawley Rats during the Development of Chronic Kidney Disease
The development of uremic cardiomyopathy (UC) and cardiac fibrosis in chronic kidney disease (CKD) was comparatively analyzed in model experiments on SPF males of Sprague–Dawley and Wistar rats. CKD was induce...
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Article
Magnetic Properties of Terbium–Lithium Tetrafluoride Crystalline Nano- and Micropowders
Terbium tetrafluoride micro- and nanopowders are synthesized. A drop in the Curie temperature of a nanosized sample is observed. The Curie temperature is TC = 2.88(4) K for a microsized sample and TC = 2.78(4) K ...
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Article
Inorganic sorbents based on magnesium silicates obtained by two synthetic routes
In the present study, three novel inorganic ion exchange materials based on magnesium silicates were synthesized by precipitation and hydrothermal sol–gel methods with two reagents ratio. Physico-chemical prop...
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Article
A-Type Granite Formation in the Yenisei Ridge in the Cryogenian Period during the Tectonic Transformation of the Region (Southwestern Framing of the Siberian Craton)
We consider the evolution of A-type granite magmatism in the Cryogenian period during a tectonic transition of the Yenisei Ridge from its postcollisional state to the early development stages of an active cont...
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Article
Open AccessMicroscopic Spin Hamiltonian for a Dipolar Heisenberg Magnet LiGdF4 from EPR Measurements
Low-temperature electron paramagnetic resonance measurements are performed on single crystals of LiY1 ‒xGdxF4 with low \(x = 0.005\) ...
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Article
Analysis of the Hypothalamic Orexinergic System in Rats with Different Forms of Genetically Determined Epilepsy
The hypothalamic orexigenic system was studied in mature males of two rat strains with a genetic predisposition to various forms of epileptic activity: Krushinsky–Molodkina (KM) rats characterized by audiogeni...
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Article
Development of Approaches to Reducing the Effective Gonadotropin Dose in Treating Androgen Insufficiency in Male Rats with Type 1 Diabetes Mellitus
In type 1 diabetes mellitus (DM1), testicular synthesis of testosterone is impaired, leading to androgen insufficiency and disorders of spermatogenesis. Long-term use of high gonadotropin doses for the correct...
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Article
Orexin-Immunopositive Structures in the Thalamic Reticular Nucleus
Orexin-A and orexin-B were immunolocalized in laboratory rodents (adult Wistar and Sprague–Dawley rats, C57Bl/6J mice) in neurons of different areas of the thalamic reticular nucleus, where the level of their ...
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Article
Melanocortin 1 Receptors in the Hypothalamus of Mice within the Norm and in Diet-Induced Obesity
The hypothalamic melanocortin system plays a key role in the regulation of eating behavior and peripheral metabolism, and its activity changes significantly in metabolic disorders. However, the possible role o...
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Article
Some synthesis aspects for poorly crystalline porous sodium titanium silicate
New approaches to synthesize poorly crystalline titanium silicate Na2Ti2SiO7·2H2O which possesses the selectivity to adsorb cesium radionuclides by using inorganic precursors have been proposed. The mechanism of ...
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Article
Study of Rheological and Structural Properties of Modified Carboxymethyl Cellulose Solutions Using Crosslinking Agents Based on Substituted Oxyranes
Modified carboxymethyl cellulose (CMC) biopolymer materials are widely used in various fields of medicine. For different medical purpose and therapeutic goals, it is required to regulate the degree of biodegra...
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Article
Comparative Study of the Restoring Effect of Metformin, Gonadotropin, and Allosteric Agonist of Luteinizing Hormone Receptor on Spermatogenesis in Male Rats with Streptozotocin-Induced Type 2 Diabetes Mellitus
We compared the effectiveness of human chorionic gonadotropin (hCG; 5 days, 20 IU/rat/day), allosteric luteinizing hormone receptor agonist TP04 (5 days, 20 mg/kg/day), and metformin (28 days, 120 mg/kg/day) i...
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Article
The Role of the AgRP 25-51 Active Fragment in the Regulation of Functional Activity of Locus Coeruleus Norepinephrinergic Neurons and in Norepinephrine Biosynthesis
Double fluorescence immunolabeling and confocal microscopy showed that the nerve processes immediately surrounding norepinephrinergic (NE) neurons in the brainstem locus coeruleus (LC) are immunopositive to Ag...
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Article
Effects of Diet-Induced and Melanocortin Obesity on the Expression of Tryptophan Hydroxylase 2 in Midbrain and Hypothalamus Neurons in Mice
The serotonin system of the brain plays key roles in regulating behavior and cognitive functions, as well as in energy metabolism. This involves serotoninergic neurons in the midbrain expressing the enzyme try...
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Article
The Effect of Low-Molecular-Weight Allosteric Agonist of Luteinizing Hormone Receptor on Functional State of the Testes in Aging and Diabetic Rats
Human chorionic gonadotropin that is widely used for improving spermatogenesis. The effect of chorionic gonadotropin is mediated through luteinizing hormone receptor. Treatment with gonadotropin is associated ...
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Article
Catalytic Properties of P- And S-Containing Acidic Carbons in the Reaction of Rapeseed Oil Transesterification with Ethanol
The catalytic activity of P- and S-containing acidic carbon materials synthesized from chloromethylene copolymer (HMS) and spherical carbonized resin (SCS) in the transesterification reaction of rapeseed oil w...
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Article
Studies of the Effects of Monoamines on Orexinergic Neurons in the Hypothalamus of Rat Embryos
Hypothalamic orexinergic neurons are involved in controlling various body functions, particularly energy balance, feeding behavior, wakefulness, and awakening. The direct effects of brain dopamine and serotoni...
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Article
Effect of Low-Molecular-Weight Allosteric Agonists of the Luteinizing Hormone Receptor on Its Expression and Distribution in Rat Testes
Human chorionic gonadotropin (hCG) and luteinizing hormone (LH) regulate testicular steroidogenesis by interacting with the orthosteric site located in the extracellular domain of the LH receptor (LHR). The us...
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Article
Effects of Prenatal Stress on the Formation of the Orexinergic System of the Hypothalamus in Rats
The effects of prenatal stress (PNS) on the formation of the orexinergic and dopaminergic systems of the brain were studied in 14- and 30-day-old rat pups born to females subjected to sleep deprivation (6 h/da...
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Article
Localization of 5-HT2C and 5-HT1B Serotonin Receptors in Orexinergic Neurons of the Hypothlamic Perifornical Area of Rodents
Both the orexin peptides produced from prepro-orexin in orexinergic neurons of the lateral hypothalamus and hypothalamic perifornical area (PFA) and serotonin coming to these hypothalamic areas from synaptic e...
