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Article
A Test-Replicate Approach to Candidate Gene Research on Addiction and Externalizing Disorders: A Collaboration Across Five Longitudinal Studies
This study presents results from a collaboration across five longitudinal studies seeking to test and replicate models of gene–environment interplay in the development of substance use and externalizing disord...
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Article
Correction: Corrigendum: Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses
Nat. Genet. 48, 624–633 (2016); published online 18 April 2016; corrected after print 27 June 2016 In the version of this article initially published, the following co-authors and their affiliations were incor...
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Article
Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses
Daniel Benjamin, Meike Bartels, Philipp Koellinger and colleagues report a genome-wide association meta-analysis of subjective well-being, depressive symptoms and neuroticism. The study leverages a large sampl...
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Article
Genome-wide association study identifies 74 loci associated with educational attainment
A genome-wide association study in 293,723 individuals identifies 74 genetic variants associated with educational attainment, which, although only explaining a small proportion of the variation in educational ...
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Article
Association of the OPRM1 Variant rs1799971 (A118G) with Non-Specific Liability to Substance Dependence in a Collaborative de novo Meta-Analysis of European-Ancestry Cohorts
The mu1 opioid receptor gene, OPRM1, has long been a high-priority candidate for human genetic studies of addiction. Because of its potential functional significance, the non-synonymous variant rs1799971 (A118G, ...
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Article
Open AccessMeta-analysis of Genome-Wide Association Studies for Extraversion: Findings from the Genetics of Personality Consortium
Extraversion is a relatively stable and heritable personality trait associated with numerous psychosocial, lifestyle and health outcomes. Despite its substantial heritability, no genetic variants have been det...
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Article
Open AccessA computational method for genotype calling in family-based sequencing data
As sequencing technologies can help researchers detect common and rare variants across the human genome in many individuals, it is known that jointly calling genotypes across multiple individuals based on link...
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Article
Romantic Relationship Satisfaction Moderates the Etiology of Adult Personality
The heritability of major normative domains of personality is well-established, with approximately half the proportion of variance attributed to genetic differences. In the current study, we examine the possib...
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Article
Genome-Wide Association Study of Behavioral Disinhibition in a Selected Adolescent Sample
Behavioral disinhibition (BD) is a quantitative measure designed to capture the heritable variation encompassing risky and impulsive behaviors. As a result, BD represents an ideal target for discovering genet...
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Article
Replication of a Gene–Environment Interaction Via Multimodel Inference: Additive-Genetic Variance in Adolescents’ General Cognitive Ability Increases with Family-of-Origin Socioeconomic Status
The present study of general cognitive ability attempts to replicate and extend previous investigations of a biometric moderator, family-of-origin socioeconomic status (SES), in a sample of 2,494 pairs of adol...
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Article
Parent–Offspring Similarity for Drinking: A Longitudinal Adoption Study
Parent–offspring resemblance for drinking was investigated in a sample of 409 adopted and 208 non-adopted families participating in the Sibling Interaction and Behavior Study. Drinking data was available for 1...
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Article
Delineating Selection and Mediation Effects Among Childhood Personality and Environmental Risk Factors in the Development of Adolescent Substance Abuse
Utilizing the large, longitudinal Minnesota Twin Family Study (N = 2510; 96 % European American ancestry), we examined the influence of several person-environment transactions on adolescent substance abuse. We fo...
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Article
Open AccessHarmonization of Neuroticism and Extraversion phenotypes across inventories and cohorts in the Genetics of Personality Consortium: an application of Item Response Theory
Mega- or meta-analytic studies (e.g. genome-wide association studies) are increasingly used in behavior genetics. An issue in such studies is that phenotypes are often measured by different instruments across ...
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Article
Adolescent Drinking and Motivated Decision-Making: A Cotwin-Control Investigation with Monozygotic Twins
The present study used a monozygotic (MZ) cotwin-control (CTC) design to investigate associations between alcohol use and performance on the Iowa gambling task (IGT) in a sample of 96 adolescents (half female)...
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Article
Preference on Cash-Choice Task Predicts Externalizing Outcomes in 17-Year-Olds
Delay-discounting, the tendency to prefer a smaller-sooner reward to a larger-later reward, has been associated with a range of externalizing behaviors. Laboratory delay-discounting tasks have emerged as a use...
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Chapter
The Adolescent Origins of Substance Use Disorders: A Behavioral Genetic Perspective
Over the past 20 years, there has been an increasing recognition within the substance abuse research field that substance use disorders (SUDs) are usefully conceptualized within a developmental framework. That is...
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Article
The Role of Constraint in the Development of Nicotine, Marijuana, and Alcohol Dependence in Young Adulthood
The personality-related construct of behavioral disinhibition is hypothesized to confer a generalized risk for alcohol and drug dependence. On average, rates of substance use and scores on measures of disinhib...
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Article
Shared Environmental Influences on Personality: A Combined Twin and Adoption Approach
In the past, shared environmental influences on personality traits have been found to be negligible in behavior genetic studies (e.g., Bouchard and McGue, J Neurobiol 54:4–45, 2003). However, most studies have be...
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Article
A Genome-Wide Association Study of Behavioral Disinhibition
We report results from a genome wide association study (GWAS) of five quantitative indicators of behavioral disinhibition: nicotine, alcohol consumption, alcohol dependence, illicit drugs, and non-substance re...
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Article
Peer Deviance, Alcohol Expectancies, and Adolescent Alcohol Use: Explaining Shared and Nonshared Environmental Effects Using an Adoptive Sibling Pair Design
Previous research suggests adolescent alcohol use is largely influenced by environmental factors, yet little is known about the specific nature of this influence. We hypothesized that peer deviance and alcohol...
