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Article
Open AccessLeveraging functional genomic annotations and genome coverage to improve polygenic prediction of complex traits within and between ancestries
We develop a method, SBayesRC, that integrates genome-wide association study (GWAS) summary statistics with functional genomic annotations to improve polygenic prediction of complex traits. Our method is scala...
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Article
Open AccessDistinct and shared genetic architectures of gestational diabetes mellitus and type 2 diabetes
Gestational diabetes mellitus (GDM) is a common metabolic disorder affecting more than 16 million pregnancies annually worldwide1,2. GDM is related to an increased lifetime risk of type 2 diabetes (T2D)1–3, with ...
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Article
Open AccessMendelian imputation of parental genotypes improves estimates of direct genetic effects
Effects estimated by genome-wide association studies (GWASs) include effects of alleles in an individual on that individual (direct genetic effects), indirect genetic effects (for example, effects of alleles i...
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Article
Open AccessWithin-sibship genome-wide association analyses decrease bias in estimates of direct genetic effects
Estimates from genome-wide association studies (GWAS) of unrelated individuals capture effects of inherited variation (direct effects), demography (population stratification, assortative mating) and relatives ...
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Article
Open AccessPolygenic prediction of educational attainment within and between families from genome-wide association analyses in 3 million individuals
We conduct a genome-wide association study (GWAS) of educational attainment (EA) in a sample of ~3 million individuals and identify 3,952 approximately uncorrelated genome-wide-significant single-nucleotide po...
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Article
Resource profile and user guide of the Polygenic Index Repository
Polygenic indexes (PGIs) are DNA-based predictors. Their value for research in many scientific disciplines is growing rapidly. As a resource for researchers, we used a consistent methodology to construct PGIs ...
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Article
Open AccessGenomic analysis of diet composition finds novel loci and associations with health and lifestyle
We conducted genome-wide association studies (GWAS) of relative intake from the macronutrients fat, protein, carbohydrates, and sugar in over 235,000 individuals of European ancestries. We identified 21 unique...
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Article
Author Correction: Multi-trait analysis of genome-wide association summary statistics using MTAG
In the version of the paper initially published, no competing interests were declared. The ‘Competing interests’ statement should have stated that B.M.N. is on the Scientific Advisory Board of Deep Genomics. T...
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Publisher Correction: Multi-trait analysis of genome-wide association summary statistics using MTAG
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Identification of common genetic risk variants for autism spectrum disorder
Autism spectrum disorder (ASD) is a highly heritable and heterogeneous group of neurodevelopmental phenotypes diagnosed in more than 1% of children. Common genetic variants contribute substantially to ASD susc...
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Article
Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences
Humans vary substantially in their willingness to take risks. In a combined sample of over 1 million individuals, we conducted genome-wide association studies (GWAS) of general risk tolerance, adventurousness,...
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Article
Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder
Attention deficit/hyperactivity disorder (ADHD) is a highly heritable childhood behavioral disorder affecting 5% of children and 2.5% of adults. Common genetic variants contribute substantially to ADHD suscept...
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Article
Imprint of assortative mating on the human genome
Preference for mates with similar phenotypes; that is, assortative mating, is widely observed in humans1–5 and has evolutionary consequences6–8. Under Fisher's classical theory6, assortative mating is predicted t...
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Article
Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals
Here we conducted a large-scale genetic association analysis of educational attainment in a sample of approximately 1.1 million individuals and identify 1,271 independent genome-wide-significant SNPs. For the ...
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Article
Multi-trait analysis of genome-wide association summary statistics using MTAG
We introduce multi-trait analysis of GWAS (MTAG), a method for joint analysis of summary statistics from genome-wide association studies (GWAS) of different traits, possibly from overlap** samples. We apply ...
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Article
Correction: Corrigendum: Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses
Nat. Genet. 48, 624–633 (2016); published online 18 April 2016; corrected after print 27 June 2016; corrected after print 29 August 2016 In the version of this article initially published, one of the affiliati...
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Article
Correction: Corrigendum: Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses
Nat. Genet. 48, 624–633 (2016); published online 18 April 2016; corrected after print 27 June 2016 In the version of this article initially published, the following co-authors and their affiliations were incor...
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Article
Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses
Daniel Benjamin, Meike Bartels, Philipp Koellinger and colleagues report a genome-wide association meta-analysis of subjective well-being, depressive symptoms and neuroticism. The study leverages a large sampl...
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Article
Genome-wide association study identifies 74 loci associated with educational attainment
A genome-wide association study in 293,723 individuals identifies 74 genetic variants associated with educational attainment, which, although only explaining a small proportion of the variation in educational ...
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