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Article
Open AccessGenetic and Environmental Variation in Continuous Phenotypes in the ABCD Study®
Twin studies yield valuable insights into the sources of variation, covariation and causation in human traits. The ABCD Study® (abcdstudy.org) was designed to take advantage of four universities known for thei...
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Uncovering the genetic architecture of broad antisocial behavior through a genome-wide association study meta-analysis
Despite the substantial heritability of antisocial behavior (ASB), specific genetic variants robustly associated with the trait have not been identified. The present study by the Broad Antisocial Behavior Cons...
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Article
Open AccessA saturated map of common genetic variants associated with human height
Common single-nucleotide polymorphisms (SNPs) are predicted to collectively explain 40–50% of phenotypic variation in human height, but identifying the specific variants and associated regions requires huge sa...
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Article
Resource profile and user guide of the Polygenic Index Repository
Polygenic indexes (PGIs) are DNA-based predictors. Their value for research in many scientific disciplines is growing rapidly. As a resource for researchers, we used a consistent methodology to construct PGIs ...
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The role of parental genotype in predicting offspring years of education: evidence for genetic nurture
Similarities between parent and offspring are widespread in psychology; however, shared genetic variants often confound causal inference for offspring outcomes. A polygenic score (PGS) derived from genome-wide...
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Adolescent Sexual Development and Peer Groups: Reciprocal Associations and Shared Genetic and Environmental Influences
Peer groups influence the emergence of sexual behaviors in adolescence, but many details regarding the mechanisms underlying these effects have yet to be described. We examined the phenotypic, genetic, and env...
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Open AccessExpanding the genetic architecture of nicotine dependence and its shared genetics with multiple traits
Cigarette smoking is the leading cause of preventable morbidity and mortality. Genetic variation contributes to initiation, regular smoking, nicotine dependence, and cessation. We present a Fagerström Test for...
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Open AccessMeta-analysis of up to 622,409 individuals identifies 40 novel smoking behaviour associated genetic loci
Smoking is a major heritable and modifiable risk factor for many diseases, including cancer, common respiratory disorders and cardiovascular diseases. Fourteen genetic loci have previously been associated with...
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Adolescent Externalizing Psychopathology and Its Prospective Relationship to Marijuana Use Development from Age 14 to 30: Replication Across Independent Longitudinal Twin Samples
Externalizing psychopathology in early adolescence is a highly heritable risk factor for drug use, yet how it relates to marijuana use development is not well-characterized. We evaluate this issue in independe...
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Free Will, Determinism, and Intuitive Judgments About the Heritability of Behavior
The fact that genes and environment contribute differentially to variation in human behaviors, traits and attitudes is central to the field of behavior genetics. Perceptions about these differential contributi...
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Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use
Tobacco and alcohol use are leading causes of mortality that influence risk for many complex diseases and disorders1. They are heritable2,3 and etiologically related4,5 behaviors that have been resistant to gene ...
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Article
Open AccessEndophenotypes in psychiatric disease: prospects and challenges
Endophenotypes, quantitative neurobehavioral traits that index genetic susceptibility for a psychiatric disorder, have been examined in thousands of studies. Nevertheless, they have underexploited potential to...
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Article
The Developmental Unfolding of Sibling Influences on Alcohol Use over Time
Research has long demonstrated that siblings are similar in their alcohol use, however much of this work relies on cross-sectional samples or samples of adolescents alone and/or exclusive focus on older siblin...
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Erratum: Genome-wide association meta-analysis of 78,308 individuals identifies new loci and genes influencing human intelligence
Nat. Genet.; doi:10.1038/ng.3869; corrected online 31 May 2017 In the version of this article initially published online, heritability was misspelled in the penultimate sentence of the abstract. The error has ...
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Article
Higher Rates of DZ Twinning in a Twenty-First Century Birth Cohort
The Colorado Twin Registry is a population based registry initiated in 1984 with the involvement of the Colorado Department of Health, Division of Vital Statistics. Recruitment includes birth cohorts several y...
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Genome-wide association meta-analysis of 78,308 individuals identifies new loci and genes influencing human intelligence
Danielle Posthuma and colleagues perform a large meta-analysis for intelligence and determine genetic overlap with several neuropsychiatric and metabolic traits. They find 15 new significant loci and implicate...
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Article
Open AccessFine map** genetic associations between the HLA region and extremely high intelligence
General cognitive ability (intelligence) is one of the most heritable behavioural traits and most predictive of socially important outcomes and health. We hypothesized that some of the missing heritability of ...
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Article
Genetic evidence of assortative mating in humans
In human populations, assortative mating is almost universally positive, with similarities between partners for quantitative phenotypes1–6, common disease risk1,3,7–10, behaviour6,11, social factors12–14 and ...
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Article
Genome-wide analysis identifies 12 loci influencing human reproductive behavior
Melinda Mills, Nicola Barban, Harold Snieder, Marcel den Hoed and colleagues perform a meta-analysis of data from over 300,000 individuals for age at first birth and number of children ever born. They identify...
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Article
Next-generation genotype imputation service and methods
Christian Fuchsberger, Gonçalo Abecasis and colleagues describe a new web-based imputation service that enables rapid imputation of large numbers of samples and allows convenient access to large reference pane...
