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Article
Three Mutually Informative Ways to Understand the Genetic Relationships Among Behavioral Disinhibition, Alcohol Use, Drug Use, Nicotine Use/Dependence, and Their Co-occurrence: Twin Biometry, GCTA, and Genome-Wide Scoring
Behavioral disinhibition is a trait hypothesized to represent a general vulnerability to the development of substance use disorders. We used a large community-representative sample (N = 7,188) to investigate t...
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Article
The interplay of genes and adolescent development in substance use disorders: leveraging findings from GWAS meta-analyses to test developmental hypotheses about nicotine consumption
The present study evaluated gene by development interaction in cigarettes smoked per day (CPD) in a longitudinal community-representative sample (N = 3,231) of Caucasian twins measured at ages 14, 17, 20, and 24....
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Article
Genetic and Environmental Contributions to the Association Between Anthropometric Measures and IQ: A Study of Minnesota Twins at Age 11 and 17
Associations of height and head circumference with IQ are well documented, but much less is known about the association of IQ with other anthropometric measures or the mechanisms behind these associations. We ...
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Article
Is the Continuity of Externalizing Psychopathology the Same in Adolescents and Middle–Aged Adults? A Test of the Externalizing Spectrum’s Developmental Coherence
Externalizing psychopathology (EXT) is a framework for understanding diagnostic comorbidity and etiology of antisocial and substance-use behaviors. EXT indicates continuity in adulthood but the structure of ad...
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Article
Psychometric and Genetic Architecture of Substance Use Disorder and Behavioral Disinhibition Measures for Gene Association Studies
Using large twin, family, and adoption studies conducted at the Minnesota Center for Twin and Family Research, we describe our efforts to develop measures of substance use disorder (SUD) related phenotypes for...
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Article
Age-of-Onset or Behavioral Sub-Types? A Prospective Comparison of Two Approaches to Characterizing the Heterogeneity within Antisocial Behavior
There are two common approaches to sub-ty** the well-documented heterogeneity within antisocial behavior: age-of-onset (i.e., childhood-onset versus adolescence-onset; see Moffitt 1993) and behavioral (i.e., ph...
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Article
The Relationship between Parent-Child Conflict and Adolescent Antisocial Behavior: Confirming Shared Environmental Mediation
Prior studies have indicated that the relationship between parent-child conflict and adolescent antisocial behavior is at least partially shared environmental in origin. However, all available research on this...
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Article
Harsh Discipline, Childhood Sexual Assault, and MAOA Genotype: An Investigation of Main and Interactive Effects on Diverse Clinical Externalizing Outcomes
We studied the impact of MAOA genotype, childhood sexual assault, and harsh discipline on clinical externalizing symptoms (substance problems, adult antisocial behavior, and conduct disorder). Participants wer...
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Article
Open AccessTime-Frequency Data Reduction for Event Related Potentials: Combining Principal Component Analysis and Matching Pursuit
Joint time-frequency representations offer a rich representation of event related potentials (ERPs) that cannot be obtained through individual time or frequency domain analysis. This representation, however, c...
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Article
Environmental Contributions to the Stability of Antisocial Behavior over Time: Are They Shared or Non-shared?
It has recently been argued that shared environmental influences are moderate, identifiable, and persistent sources of individual differences in most forms of child and adolescent psychopathology, including an...
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Article
Brain Electrophysiological Endophenotypes for Externalizing Psychopathology: A Multivariate Approach
Abnormalities in electrophysiological measures of stimulus-evoked brain activity (including the P3 event-related potential (ERP) and its associated delta and theta time–frequency (TF) components), and intrinsi...
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Article
Are there Shared Environmental Influences on Adolescent behavior? Evidence from a Study of Adoptive Siblings
The failure to identify specific non-shared environmental influences on behavior coupled with the belief that shared environmental factors contribute minimally to individual differences in behavior has led to ...
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Article
A Twin Study of the Genetics of High Cognitive Ability Selected from 11,000 Twin Pairs in Six Studies from Four Countries
Although much genetic research has addressed normal variation in intelligence, little is known about the etiology of high cognitive abilities. Using data from 11,000 twin pairs (age range = 6–71 years) from th...
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Article
Shared-Environmental Contributions to High Cognitive Ability
Using a combined sample of adolescent twins, biological siblings, and adoptive siblings, we estimated and compared the differential shared-environmentality for high cognitive ability and the shared-environment...
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Article
Construct Validity of Adolescent Antisocial Personality Disorder
This study examined the construct validity of antisocial personality disorder (ASPD) diagnosed in adolescence. Boys and girls were grouped by history of DSM-III-R conduct disorder (CD) and ASPD: Controls (n=340) ...
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Article
Environmental Contributions to Adolescent Delinquency: A Fresh Look at the Shared Environment
Few genetically-informative studies have attempted to explicitly identify the shared environmental (i.e., those environmental influences that contribute to sibling similarity) factors now known to contribute to a...
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Article
The Environments of Adopted and Non-adopted Youth: Evidence on Range Restriction From the Sibling Interaction and Behavior Study (SIBS)
Previous reviews of the literature have suggested that shared environmental effects may be underestimated in adoption studies because adopted individuals are exposed to a restricted range of family environment...
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Article
The Association of Early Adolescent Problem Behavior and Adult Psychopathology: A Multivariate Behavioral Genetic Perspective
Research has documented a strong association between early adolescent problem behavior and adult disinhibitory psychopathology, leading some to suggest that the latter can be reduced by preventing or delaying ...
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Article
Genetic and Environmental Influences on Adolescents’ Perceptions of Current Family Environment
Previous studies of the genetic and environmental components of the Family Environment Scale (FES) have typically reported that scales relating to familial acceptance are moderately to strongly genetically inf...
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Article
Genetic and Environmental Influences on Psychopathy Trait Dimensions in a Community Sample of Male Twins
Psychopathy appears to be comprised of two broad dimensions: impulsivity/antisocial behavior and interpersonal detachment/callousness. This study examined the extent to which variance in these 2 psychopathy tr...
