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Article
Open AccessA Re-evaluation of Candidate Gene Studies for Well-Being in Light of Genome-Wide Evidence
Ever since twin-family studies found that a substantial amount (± 40%) of the variation in well-being can be explained by genetic variation, several candidate genes have been proposed explaining this variation...
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Article
Open AccessExpanding the environmental scope: an environment-wide association study for mental well-being
Identifying modifiable factors associated with well-being is of increased interest for public policy guidance. Developments in record linkage make it possible to identify what contributes to well-being from a ...
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Article
Open AccessDNA methylation signatures of aggression and closely related constructs: A meta-analysis of epigenome-wide studies across the lifespan
DNA methylation profiles of aggressive behavior may capture lifetime cumulative effects of genetic, stochastic, and environmental influences associated with aggression. Here, we report the first large meta-ana...
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Article
Open AccessSmartphone-Based Ecological Momentary Assessment of Well-Being: A Systematic Review and Recommendations for Future Studies
Feelings of well-being and happiness fluctuate over time and contexts. Ecological Momentary Assessment (EMA) studies can capture fluctuations in momentary behavior, and experiences by assessing these multiple ...
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Article
Open AccessA Comparison of the ASEBA Adult Self Report (ASR) and the Brief Problem Monitor (BPM/18-59)
The adult self report (ASR) is a well-validated instrument with multiple scales relating to adult psychopathology. Recently, an 18-item version has been introduced, the brief problem monitor (BPM) to measure I...
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Article
Author Correction: GWAS of lifetime cannabis use reveals new risk loci, genetic overlap with psychiatric traits, and a causal effect of schizophrenia liability
Several occurrences of the word ‘schizophrenia’ have been re-worded as ‘liability to schizophrenia’ or ‘schizophrenia risk’, including in the title, which should have been “GWAS of lifetime cannabis use reveal...
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Article
Multivariate genome-wide analyses of the well-being spectrum
We introduce two novel methods for multivariate genome-wide-association meta-analysis (GWAMA) of related traits that correct for sample overlap. A broad range of simulation scenarios supports the added value o...
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Article
GWAS of lifetime cannabis use reveals new risk loci, genetic overlap with psychiatric traits, and a causal effect of schizophrenia liability
Cannabis use is a heritable trait that has been associated with adverse mental health outcomes. In the largest genome-wide association study (GWAS) for lifetime cannabis use to date (N = 184,765), we identified e...
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Article
Correction: Corrigendum: Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses
Nat. Genet. 48, 624–633 (2016); published online 18 April 2016; corrected after print 27 June 2016; corrected after print 29 August 2016 In the version of this article initially published, one of the affiliati...
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Article
Correction: Corrigendum: Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses
Nat. Genet. 48, 624–633 (2016); published online 18 April 2016; corrected after print 27 June 2016 In the version of this article initially published, the following co-authors and their affiliations were incor...
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Article
Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses
Daniel Benjamin, Meike Bartels, Philipp Koellinger and colleagues report a genome-wide association meta-analysis of subjective well-being, depressive symptoms and neuroticism. The study leverages a large sampl...
