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Article
Dimensional and transdiagnostic phenotypes in psychiatric genome-wide association studies
Genome-wide association studies (GWAS) provide biological insights into disease onset and progression and have potential to produce clinically useful biomarkers. A growing body of GWAS focuses on quantitative ...
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Article
A review of approaches and models in psychopathology conceptualization research
Mental disorder classification provides a definitional framework that underlies applied clinical and research efforts to understand, assess, predict, prevent and ameliorate the burden of psychopathology. Many ...
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Article
Open AccessNeurobehavioral Mechanisms of Comorbidity in Internalizing and Externalizing Psychopathology: An RDoC Multimethod Assessment
This study links different-modality indicators of RDoC constructs (self-reports, behavior, and error-related brain activity) to explore their association with internalizing and externalizing dimensions of psyc...
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Article
Diversity and the Hierarchical Taxonomy of Psychopathology (HiTOP)
The Hierarchical Taxonomy of Psychopathology (HiTOP) is an empirically based, hierarchical model of the structure of psychopathology that was created in response to the limitations of traditional, categorical ...
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Article
Open AccessChanging genetic architecture of body mass index from infancy to early adulthood: an individual based pooled analysis of 25 twin cohorts
Body mass index (BMI) shows strong continuity over childhood and adolescence and high childhood BMI is the strongest predictor of adult obesity. Genetic factors strongly contribute to this continuity, but it i...
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Article
The weight of childhood adversity: evidence that childhood adversity moderates the impact of genetic risk on waist circumference in adulthood
The present study tested the interactive effects of childhood adversity and polygenic risk scores for waist circumference (PRS-WC) on waist circumference (WC). Consistent with a diathesis-stress model, we hypo...
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Article
Psychiatric disorders and risk for multiple adverse outcomes: a national prospective study
Most psychiatric disorders, when examined individually, are associated with a broad range of adverse outcomes. However, psychiatric disorders often co-occur and their co-occurrence is well explained by a limit...
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Article
Open AccessGenetic and environmental variation in educational attainment: an individual-based analysis of 28 twin cohorts
We investigated the heritability of educational attainment and how it differed between birth cohorts and cultural–geographic regions. A classical twin design was applied to pooled data from 28 cohorts represen...
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Article
Open AccessGenetic and environmental influences on human height from infancy through adulthood at different levels of parental education
Genetic factors explain a major proportion of human height variation, but differences in mean stature have also been found between socio-economic categories suggesting a possible effect of environment. By util...
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Chapter
Moderators of Genetic and Environmental Influences on Personality: Empirical and Theoretical Considerations
This chapter reviews the extant literature on gene-by-environment (GxE) interactions as they affect personality and individual differences. The introduction puts forth the motivation for studying GxE interacti...
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Article
Open AccessBorderline personality disorder diagnosis in a new key
Conceptualizations of personality disorders (PD) are increasingly moving towards dimensional approaches. The definition and assessment of borderline personality disorder (BPD) in regard to changes in nosology ...
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Article
Schizotypy from the Perspective of the DSM-5 Alternative Model of Personality Traits: a Study on a Sample of 1056 Italian Adult University Students
To assess the relationships between schizotypy measures and DSM-5 Alternative Model of Personality Disorders (AMPD) traits, 1056 (69.4% female; mean age = 23.30 years) University students, were administered the I...
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Article
A Brief but Comprehensive Review of Research on the Alternative DSM-5 Model for Personality Disorders
Both the Alternative DSM-5 Model for Personality Disorders (AMPD) and the chapter on personality disorders (PD) in the recent version of ICD-11 embody a shift from a categorical to a dimensional paradigm for t...
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Article
Genetically Informative Mediation Modeling Applied to Stressors and Personality-Disorder Traits in Etiology of Alcohol Use Disorder
A statistical mediation model was developed within a twin design to investigate the etiology of alcohol use disorder (AUD). Unlike conventional statistical mediation models, this biometric mediation model can ...
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Article
Executive Functioning Correlates of DSM-5 Maladaptive Personality Traits: Initial Evidence from an Italian Sample of Consecutively Admitted Adult Outpatients
In order to evaluate the associations between computer-administered tasks of executive functioning (EF), and maladaptive personality domains and traits listed in DSM-5 Alternative Model of Personality Disorders, ...
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Article
Open AccessBirth size and gestational age in opposite-sex twins as compared to same-sex twins: An individual-based pooled analysis of 21 cohorts
It is well established that boys are born heavier and longer than girls, but it remains unclear whether birth size in twins is affected by the sex of their co-twin. We conducted an individual-based pooled anal...
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Article
The Role of Genes and Environments in Linking the Need to Evaluate with Political Ideology and Political Extremity
Understanding the origins of political ideology and political extremity at the individual level is becoming increasingly pressing in the face of polarization in the political domain. Building upon the motivate...
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Article
Genetic and Environmental Structure of DSM-IV Criteria for Antisocial Personality Disorder: A Twin Study
Results from previous studies on DSM-IV and DSM-5 Antisocial Personality Disorder (ASPD) have suggested that the construct is etiologically multidimensional. To our knowledge, however, the structure of genetic...
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Article
Open AccessDoes the sex of one’s co-twin affect height and BMI in adulthood? A study of dizygotic adult twins from 31 cohorts
The comparison of traits in twins from opposite-sex (OS) and same-sex (SS) dizygotic twin pairs is considered a proxy measure of prenatal hormone exposure. To examine possible prenatal hormonal influences on a...
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Article
Correction: Corrigendum: Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses
Nat. Genet. 48, 624–633 (2016); published online 18 April 2016; corrected after print 27 June 2016; corrected after print 29 August 2016 In the version of this article initially published, one of the affiliati...
