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Alkyl-Quinolones derivatives as potential biomarkers for Pseudomonas aeruginosa infection chronicity in Cystic Fibrosis
In Cystic Fibrosis (CF), a rapid and standardized definition of chronic infection would allow a better management of Pseudomonas aeruginosa ( Pa )...
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Development and validation of an LC-HRMS method for the determination of pyrrolizidine alkaloids and quinolones in honey employing a simple alkaline sample dilution
Honey residue and contaminant assessments are extremely important, as they deal with food and therapeutic safety issues of a widely consumed animal...
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Solid-Phase-Fluorimetric Determination of Quinolones in Medicinal Preparations on Cellulose Paper and in a Thin Silica Layer Using a Smartphone
AbstractA simple and an available method is proposed for the determination of quinolone antibiotics using solid-phase fluorescence digital...
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Facile synthesis of 5-aminopyrazolo-quinolones
Catalyzed by triethylamine, 4-hydrazino-quinolin-2-one derivatives and 2-(1-ethoxy-substituted-ene)malononitrile were refluxed together in ethanol to...
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Determination of 12 quinolones in honey by vortex-assisted dispersive liquid liquid microextraction performed in syringe based on deep eutectic solvent combine with ultra performance liquid chromatography-mass spectrometry
A novel vortex-assisted dispersive liquid–liquid microextraction method based on deep eutectic solvent (VA–DLLME–DES) completed in syringe has been...
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Noncovalent interactions as a solution for the metal-free one-pot asymmetric synthesis of (S)-2-aryl-2,3-dihydro-4(1H)-quinolones
4-Quinolones compose a remarkable class of compounds that show various pharmacological applications. In particular, the activities of both ( S ) and ( R )...
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Rapid Detection of Quinolone Antibiotics in Aquatic Products by Surface-Enhanced Raman Spectroscopy Combined with Thin Layer Chromatography
AbstractThis study presents the establishment of surface-enhanced Raman spectroscopy ( SERS ) combined with the thin-layer chromatography ( TLC ) method...
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Chitosan@Tannic Acid-Supported Fe3O4 Magnetic Bionanocomposite as Green and Recyclable Catalyst for the Synthesis of Benzo[g]thiazolo[3,2-a]quinolones Based on Nitroketene N,S-Acetal
To prepare an efficient magnetic bionanocomposite and to protect ferrite nanoparticles from oxidation and aggregation, the prepared Fe 3 O 4 was...
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Novel Synthetic Antibacterial Agents
Classical (fermentation-based) and nonclassical (nonfermentation-based) antibacterials are conventionally used for the treatment of bacterial... -
Antibiotic residues in milk and dairy products in China: occurrence and human health concerns
Although veterinary antibiotics are essential in preventing and treating clinical diseases in cattle, the frequent use of antibiotics leads to...
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Topological analysis and reactivity study of monomeric and dimeric forms of 2-methyl-4(1H)-quinolone: a computational study
ContextQuinolone derivatives have gathered major attention largely due to their wonderful biological activities. Quinolones are a class of molecules...
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Post‐synthetic modification of IR-MOF‐3 as acidic-basic heterogeneous catalyst for one-pot synthesis of pyrimido[4,5-b]quinolones
In this study, a modified IR-MOF-3 via a multi-step post-synthesis modification, namely IR-MOF-3-ILOAc-Fe(acac) 3 , was prepared as an ion-pair...
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Preparation of a hydrophobic deep eutectic solvent and its application in the detection of quinolone residues in cattle urine
Enrichment for the detection of quinolone residues is usually cumbersome and requires large amounts of toxic organic reagents. Therefore, this study...
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Biosynthetic flexibility of Pseudomonas aeruginosa leads to hydroxylated 2-alkylquinolones with proinflammatory host response
The human pathogen Pseudomonas aeruginosa produces various 4(1 H )-quinolones with diverse functions. Among these, 2-nonyl-4(1 H )-quinolone (NQ) and its N ...
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Quinolone scaffolds as potential drug candidates against infectious microbes: a review
Prevalence of microbial infections and new rising pathogens are signified as causative agent for variety of serious and lethal health crisis in past...
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A framework for dissecting affinities of multidrug efflux transporter AcrB to fluoroquinolones
Sufficient concentration of antibiotics close to their target is key for antimicrobial action. Among the tools exploited by bacteria to reduce the...
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Repurposing of anti-malarial drugs for the treatment of tuberculosis: realistic strategy or fanciful dead end?
BackgroundDrug repurposing offers a strategic alternative to the development of novel compounds, leveraging the known safety and pharmacokinetic...
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Multi-templates surface molecularly imprinted polymer for rapid separation and analysis of quinolones in water
Rapid separation and analysis of trace quinolones (fleroxacin (FLRX), enoxacin (EN), norfloxacin (NOR), ciprofloxacin (CIP), enrofloxacin (ENRO), and...
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Antibiotic Use in Finfish Aquaculture: Modes of Action, Environmental Fate, and Microbial Resistance
Various antibiotics have been used over the past 20 years and continue to be registered for use in finfish aquaculture in the United Kingdom,... -
Prioritization, sources, and ecological risk of typical antibiotics in the Huai River, a Chinese major river: a warning about aquaculture
This is the first comprehensive report on antibiotics in the Huai River, a major Chinese river. To illuminate the concentrations, prioritization,...