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Signaling Pathways in Plant Responses to Abiotic Stress
Recent scientific advancements have significantly improved our understanding of plant signaling pathways under abiotic stress. However, further...
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Signaling Pathways Regulating Cartilage Formation
Over the course of many years of investigation, the molecular processes that regulate the differentiation of chondrocytes throughout the development...
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Metabolites of Chemical Signaling Pathways from Crop–Microbe Interactions
Crop–microbe interactions play an important role in plant growth, development, and health. These interactions are mediated by chemical signals, which...
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The interplay between Wnt signaling pathways and microtubule dynamics
Wnt signaling pathways represent an evolutionarily highly conserved, intricate network of molecular interactions that regulates various aspects of...
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Impaired bone morphogenetic protein (BMP) signaling pathways disrupt decidualization in endometriosis
Endometriosis is linked to increased infertility and pregnancy complications due to defective endometrial decidualization. We hypothesized that...
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Intrinsic Signaling Pathways and key Regulatory Factors of Stomatal Development
Stomata are small pores on the surface of plant leaves that play a critical role in regulating gas exchange and water loss. The development of...
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Targeting Wnt/β-catenin signaling and its interplay with TGF-β and Notch signaling pathways for the treatment of chronic wounds
Wound healing is a tightly regulated process that ensures tissue repair and normal function following injury. It is modulated by activation of...
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The interaction between ferroptosis and inflammatory signaling pathways
Ferroptosis is an iron-dependent regulated cell death driven by excessive lipid peroxidation. Inflammation is one common and effective physiological...
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Tight Junctions and Signaling Pathways in Cancer
Tight junctions (TJs) are intercellular connections that close the gap between the individual cells and limit the paracellular entry of harmful...
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When AHR signaling pathways meet viral infections
Aryl hydrocarbon receptor (AHR) is a ligand-dependent transcriptional factor widely expressed among immune, epithelial, endothelial and stromal cells...
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Interplay of oxidative stress, cellular communication and signaling pathways in cancer
Cancer remains a significant global public health concern, with increasing incidence and mortality rates worldwide. Oxidative stress, characterized...
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Skeletal ciliopathy: pathogenesis and related signaling pathways
Cilia are tiny organelles with conserved structures and components in eukaryotic cells. Ciliopathy is a set of diseases resulting from cilium...
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The implication of ciliary signaling pathways for epithelial–mesenchymal transition
Epithelial-to-mesenchymal transition (EMT), which plays an essential role in development, tissue repair and fibrosis, and cancer progression, is a...
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EmbryoNet: using deep learning to link embryonic phenotypes to signaling pathways
Evolutionarily conserved signaling pathways are essential for early embryogenesis, and reducing or abolishing their activity leads to characteristic...
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A framework for Frizzled-G protein coupling and implications to the PCP signaling pathways
The ten Frizzled receptors (FZDs) are essential in Wnt signaling and play important roles in embryonic development and tumorigenesis. Among these,...
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Anti-tumor Effects of Polyphenols via Targeting Cancer Driving Signaling Pathways: A Review
The use of drugs in chemotherapy poses numerous side effects. Hence the use of natural substances that can help in the prevention and cure of the...
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A novel search engine for proteins involved in Notch crosstalk signaling pathways
To regulate biological activity in humans, the Notch signaling pathway (NSP) plays an essential role in a wide array of cellular development and...
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Extracellular matrix-induced signaling pathways in mesenchymal stem/stromal cells
The extracellular matrix (ECM) is a crucial component of the stem cell microenvironment, or stem-cell niches, and contributes to the regulation of...
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Oxidative stress in Alzheimer’s disease: current knowledge of signaling pathways and therapeutics
Alzheimer’s disease’s pathophysiology is still a conundrum. Growing number of evidences have elucidated the involvement of oxidative stress in the...
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ERF111/ABR1: An AP2 Domain Transcription Factor Serving as a Hub for Multiple Signaling Pathways
Plants can sustain under adverse conditions despite being sessile because of the presence of intricate and sophisticated signaling systems. All the...
