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Signaling Pathways Regulating Cartilage Formation

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Cartilage: From Biology to Biofabrication

Abstract

Over the course of many years of investigation, the molecular processes that regulate the differentiation of chondrocytes throughout the development of cartilage from their initial activation from mesenchymal progenitor cells to their eventual maturation into hypertrophic chondrocytes have been discovered. In this chapter, we take a glance at the interaction between a number of signaling molecules, mechanical cues, and morphological cell characteristics to activate a specific subset of crucial transcription factors that regulate the genetic program that triggers chondrogenesis and chondrocyte divergence, which leads to the formation of cartilage. We also discuss current research on how various signal transduction pathways regulate chondrocyte differentiation and multiplication in the articular surface. In adult normal cartilage, the anabolic and catabolic processes of chondrocyte maturation are delicately balanced. Due to the degradation of joint with age, the body’s ability to maintain homeostasis is compromised, catabolic pathways are triggered, and cartilage is acutely and severely prone to degeneration. Because the differentiation of cartilage and maintenance of cellular metabolism are intricately governed by a complex series of signal transduction and biophysical elements of the system, it appears that recognizing these processes will be beneficial for both exploring the molecular and biological methods for cartilage tissue engineering and identification of the disease-causing major elements for particular therapeutics for management of the disease progression. This chapter will emphasize on the key signaling pathways that can activate the cellular, subcellular, and biochemical mechanisms, controlling functional properties of the cartilage under normal circumstances. These pathways may have an impact on how various cartilage tissue compartments interact. Consequently, the study in this area may result in the development of more efficient cartilage regeneration therapies.

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  1. Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan

    Faiza Ramzan, Asmat Salim & Irfan Khan

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  1. Faiza Ramzan
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  2. Asmat Salim
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  3. Irfan Khan
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Correspondence to Irfan Khan .

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  1. Cell Science Research Center, Royan Institute, Tehran, Iran

    Mohamadreza Baghaban Eslaminejad

  2. Cell Science Research Center, Royan Institute, Tehran, Iran

    Samaneh Hosseini

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Ramzan, F., Salim, A., Khan, I. (2023). Signaling Pathways Regulating Cartilage Formation. In: Baghaban Eslaminejad, M., Hosseini, S. (eds) Cartilage: From Biology to Biofabrication. Springer, Singapore. https://doi.org/10.1007/978-981-99-2452-3_6

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