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A Study of the Metabolism of Ibutamoren (MK-677), a Growth Hormone Secretagogue, in Human Urine by Ultra-High-Performance Liquid Chromatography–High-Resolution Mass Spectrometry
AbstractThe metabolism of Ibutamoren (MK-677), a nonpeptide growth hormone secretagogue, was investigated by analyzing human urine samples collected...
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Improving predictions of compound amenability for liquid chromatography–mass spectrometry to enhance non-targeted analysis
Mass-spectrometry-based non-targeted analysis (NTA), in which mass spectrometric signals are assigned chemical identities based on a systematic...
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Analysis and Identification of Peptide Postbiotics by LC-MS, MALDI-TOF Mass Spectrometry
The systematic examination of protein identity, amount, and function is known as proteomics. The proteome is a complex and dynamic structure, in...
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Quantification of Plasma S-adenosylmethionine and S-adenosylhomocysteine Using Liquid Chromatography-Electrospray-Tandem Mass Spectrometry
We describe a simple stable isotope dilution method for accurate determination of S-adenosylmethionine (SAM) and S-adenosylhomocysteine (SAH) in...
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Determination of Umifenovir and Its Metabolites by High-Performance Liquid Chromatography with Combined Mass Spectrometric Detection
AbstractAn approach to the highly sensitive and selective determination of the bromine-containing antiviral drug umifenovir (Arbidol) and its...
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Quantification of Oxcarbazepine Using Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)
Oxcarbazepine (Trileptal®) has been found effective in the treatment of tonic-clonic seizures and partial seizures with or without secondary...
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Mass Spectrometry in Clinical Laboratory: Applications in Therapeutic Drug Monitoring and Toxicology
Mass spectrometry (MS) coupled with liquid chromatography (LC) or gas chromatography (GC) has been proven to be a powerful platform in research and...
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Plasma Lysosphingolipid Biomarker Measurement by Liquid Chromatography Tandem Mass Spectrometry
Plasma lysosphingolipids are highly elevated in patients with Gaucher, Krabbe, Fabry, and Niemann–Pick diseases and tend to accumulate to a greater...
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Determination of anti-SARS-CoV-2 virustatic pharmaceuticals in the aquatic environment using high-performance liquid chromatography high-resolution mass spectrometry
The Covid-19 pandemic has affected the global population since 2019. The rapid development and approval of vaccines has brought relief. Yet,...
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Lipidomics Analysis of Different Marine Fish Oils Using Untargeted Liquid Chromatography–Orbitrap High-Resolution Mass Spectrometry and Chemometrics
Marine fish oils (MFOs) have been known for their nutritional compounds, which benefit human health. MFOs contain various lipids which play an...
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Quantitation of Urine Nicotine, Cotinine, and 3-OH-Cotinine by Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)
Nicotine is a naturally occurring and highly addictive chemical used in e-cigarettes, cigarettes, chewing tobacco, and other tobacco products as well...
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Analyzing Activities of Lytic Polysaccharide Monooxygenases by Liquid Chromatography and Mass Spectrometry
Lytic polysaccharide monooxygenases perform oxidative cleavage of glycosidic bonds in various polysaccharides. The majority of LMPOs studied so far...
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Ultra-high-performance liquid chromatography-atmospheric pressure ionization-tandem mass spectrometry method for the migration studies of primary aromatic amines from food contact materials
This work describes the development of an ultra-high-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) method for the...
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Determination of Methylphosphonic Acid and Alkyl Methylphosphonic Acid Esters in Soils by Liquid Chromatography–High-Resolution Mass Spectrometry
AbstractA method has been optimized for simultaneous extraction of ethyl methylphosphonic acid ester (EMPA), isopropyl methylphosphonic acid ester...
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Determination of Hydrolytic Transformation Products of Sesquimustards in Water by High Resolution Liquid Chromatography/Mass Spectrometry
AbstractAn approach to the determination of five sesquimustard markers, namely, bis(2-hydroxyethylthio)methane (BHETM),...
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Study of metalation of thioredoxin by gold(I) therapeutic compounds using combined liquid chromatography/capillary electrophoresis with inductively coupled plasma/electrospray MS/MS detection
The reactivity of thioredoxin (Trx1) with the Au(I) drug auranofin (AF) and two therapeutic N-heterocyclic carbene (NHC) 2 -Au(I) complexes (bis...
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Analysis of milk with liquid chromatography–mass spectrometry: a review
As a widely consumed foodstuff, milk and dairy products are increasingly studied over the years. At the present time, milk profiling is used as a...
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Determination of Polar Veterinary Drugs and Melamine in Feeds: Method Using Ion-Pair Reversed-Phase or Hydrophilic Interaction Liquid Chromatography Coupled to Tandem Mass Spectrometry
This protocol specifies a LC-ESI-MS/MS method for the quantification of the polar veterinary drugs spectinomycin, zilpaterol, halquinol (a...
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Data Processing and Analysis in Liquid Chromatography–Mass Spectrometry-Based Targeted Metabolomics
Mass spectrometry (MS)-based metabolomics provides high-dimensional datasets; that is, the data include various metabolite features. Data analysis...
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Development, Optimization, and Validation of an Ultrasound-Assisted Liquid–Liquid Microextraction (UALLME) for Selenomethionine Analyses in Cashew Nut (Anacardium occidentale) by Ultra-Performance Liquid Chromatography Coupled to Electrospray Ionization/Single Quadrupole Mass Spectrometer (UPLC-ESI/QDa)
A method based on liquid–liquid microextraction assisted by ultrasound energy (UALLME) and UPLC-ESI/QDa detection was developed for SeMet analysis in...
