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Mass Spectrometry for Metabolomics

  • Book
  • © 2023

Overview

Editors:
  1. Raúl González-Domínguez

    1. Instituto de Investigación e Innovación Biomédica de Cádiz, Hospital Universitario Puerta del Mar, Cádiz, Spain

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  • Includes cutting-edge techniques
  • Provides step-by-step detail essential for reproducible results
  • Contains key implementation advice from the experts

Part of the book series: Methods in Molecular Biology (MIMB, volume 2571)

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About this book

This detailed volume provides a comprehensive overview of state-of-the-art metabolomics methods based on mass spectrometry (MS), and their application in food, nutrition, and biomedical research. The chapters assembled herein cover hot topics related to sample preparation, chromatographic and electrophoretic separation, MS-based analysis, as well as data processing and analysis. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. 

Authoritative and cutting-edge, Mass Spectrometry for Metabolomics serves as a timely guide for chemists, biochemists, biologists, nutritionists, clinicians, and other experts working in the growing and exciting field of metabolomics.

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Table of contents (22 protocols)

  1. Front Matter

    Pages i-xv
    Download chapter PDF

  2. Comprehensive and High-Throughput Method for Quantitative Fingerprinting of Phenolic Compounds

    • Raúl González-Domínguez, Ana Sayago, María Santos-Martín, Ángeles Fernández-Recamales
    Pages 1-12

  3. Determination of Volatile Metabolites in Vinegar by Solid-Phase Microextraction–Gas Chromatography–Mass Spectrometry (SPME–GC–MS)

    • Remedios Castro, Enrique Durán-Guerrero
    Pages 13-20

  4. Determination of Volatile Metabolites in Vinegar by Stir Bar Sorptive Extraction–Gas Chromatography–Mass Spectrometry (SBSE–GC–MS)

    • Enrique Durán-Guerrero, Remedios Castro
    Pages 21-32

  5. Discovery of Food Intake Biomarkers Using Metabolomics

    • Leticia Lacalle-Bergeron, David Izquierdo-Sandoval, Juan V. Sancho, Tania Portolés
    Pages 33-43

  6. Metabolomic Characterization of the Antiproliferative Activity of Bioactive Compounds from Fruit By-Products Against Colon Cancer Cells

    • Gerardo Alvarez-Rivera, Alberto Valdés, Alejandro Cifuentes
    Pages 45-55

  7. Untargeted Metabolomics by Liquid Chromatography–Mass Spectrometry in Biomedical Research

    • Caridad Díaz, Carmen González-Olmedo
    Pages 57-69

  8. Untargeted Metabolomics for Disease-Specific Signatures

    • Constantina Chalikiopoulou, José Carlos Gómez-Tamayo, Theodora Katsila
    Pages 71-81

  9. Metabolomics Analysis of Blood, Urine, and Saliva Samples Based on Capillary Electrophoresis–Mass Spectrometry

    • Masahiro Sugimoto, Yumi Aizawa
    Pages 83-94

  10. Capillary Electrophoresis–Mass Spectrometry for the Direct Analysis of Metabolites in Highly Saline Samples Using In-Capillary Preconcentration

    • Marlien van Mever, Rawi Ramautar
    Pages 95-103

  11. Chemical Derivatization to Enhance Capillary Electrophoresis Mass Spectrometric Analysis of Acidic Metabolites in Mammalian Cells

    • Marlien van Mever, Rawi Ramautar
    Pages 105-114

  12. Untargeted Metabolomics Based on Liquid Chromatography–Mass Spectrometry for the Analysis of Plasma and Erythrocyte Samples in Childhood Obesity

    • Álvaro González-Domínguez, Marina Armeni, Otto Savolainen, Alfonso María Lechuga-Sancho, Rikard Landberg, Raúl González-Domínguez
    Pages 115-122

  13. Characterization of the Plasmatic and Erythroid Multielemental Biodistribution in Childhood Obesity Using a High-Throughput Method for Size Fractionation of Metal Species

    • Álvaro González-Domínguez, María Millán-Martínez, Daniel Sánchez-Rodas, Alfonso María Lechuga-Sancho, Raúl González-Domínguez
    Pages 123-132

  14. Analysis of Brain Metabolites Using Two Complementary Ultrahigh-Performance Liquid Chromatography–Mass Spectrometry Methods

    • Alexa M. Jauregui, Sofia E. Parellada, Emily Neag, Sanjoy K. Bhattacharya
    Pages 133-142

  15. Analysis of Cholesterol from the Liver Using Gas Chromatography–Mass Spectrometry

    • Meher A. Saleem, Betsy Benitez, Charles Yaros, Gabrielle Yamar, Sanjoy K. Bhattacharya
    Pages 143-148

  16. Metabolomics Analysis of Aqueous Humor Based on Liquid Chromatography–Mass Spectrometry

    • Karolina Pietrowska, Diana Anna Dmuchowska, Adam Kretowski, Michal Ciborowski
    Pages 149-155

  17. Analyses and Localization of Serotonin and L-DOPA in Ocular Tissues by Imaging Mass Spectrometry

    • Varun Krishnan, Sean Meehan, Colin Hayter, Sanjoy K. Bhattacharya
    Pages 157-168

  18. Isobaric Incorporation of C13-Histidine for the Assessment of Remyelination

    • Faith Christine Harvey, Anddre Osmar Valdivia, Colin Hayter, Sanjoy K. Bhattacharya
    Pages 169-175

  19. Isolation and Lipidomic Screening of Human Milk Extracellular Vesicles

    • Victoria Ramos-Garcia, Isabel Ten-Doménech, Abel Albiach-Delgado, Marta Gómez-Ferrer, Pilar Sepúlveda, Anna Parra-Llorca et al.
    Pages 177-188

  20. Mass Spectrometry-Based Untargeted Metabolomics and Lipidomics Platforms to Analyze Cell Culture Extracts

    • Elias Iturrospe, Katyeny Manuela da Silva, Maria van de Lavoir, Rani Robeyns, Matthias Cuykx, Tamara Vanhaecke et al.
    Pages 189-206
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Editors and Affiliations

  • Instituto de Investigación e Innovación Biomédica de Cádiz, Hospital Universitario Puerta del Mar, Cádiz, Spain

    Raúl González-Domínguez

Bibliographic Information

  • Book Title: Mass Spectrometry for Metabolomics

  • Editors: Raúl González-Domínguez

  • Series Title: Methods in Molecular Biology

  • DOI: https://doi.org/10.1007/978-1-0716-2699-3

  • Publisher: Humana New York, NY

  • eBook Packages: Springer Protocols

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 2023

  • Hardcover ISBN: 978-1-0716-2698-6Published: 25 September 2022

  • Softcover ISBN: 978-1-0716-2701-3Published: 25 September 2023

  • eBook ISBN: 978-1-0716-2699-3Published: 24 September 2022

  • Series ISSN: 1064-3745

  • Series E-ISSN: 1940-6029

  • Edition Number: 1

  • Number of Pages: XV, 272

  • Number of Illustrations: 5 b/w illustrations, 51 illustrations in colour

  • Topics: Mass Spectrometry, Cell Biology

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