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Development of SV2A Ligands for Epilepsy Treatment: A Review of Levetiracetam, Brivaracetam, and Padsevonil
Epilepsy is a common neurological disorder that is primarily treated with antiseizure medications (ASMs). Although dozens of ASMs are available in...
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Brivaracetam Modulates Short-Term Synaptic Activity and Low-Frequency Spontaneous Brain Activity by Delaying Synaptic Vesicle Recycling in Two Distinct Rodent Models of Epileptic Seizures
Brivaracetam (BRV) is an anti-seizure drug for the treatment of focal and generalized epileptic seizures shown to augment short-term synaptic fatigue...
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Channeling of New Neuropsychiatric Drugs—Impact on Safety and Effectiveness Studies
This study aimed to examine differential prescribing due to channeling and propensity score non-overlap over time in new versus established...
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Efficacy and tolerability of brivaracetam in patients with intellectual disability and epilepsy
Patients with intellectual disability (ID) are often excluded from clinical trials, and little is known about the best approach to treat their...
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Lennox-Gastaut Syndrome: Current Treatments, Novel Therapeutics, and Future Directions
Lennox-Gastaut syndrome is a severe drug-resistant developmental and epileptic encephalopathy with slow spike and wave on EEG (DEE-SSW) composing...
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Doses Evaluated in Clinical Pharmacology Studies Investigating the Effect of Intrinsic and Extrinsic Factors on PK and Safety: Case Examples from Approved Drug Development Programs
Dose selection for investigations of intrinsic and extrinsic factors of pharmacokinetic variability as well as safety is a challenging question in...
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Physiologically Based Pharmacokinetic Modeling to Unravel the Drug-gene Interactions of Venlafaxine: Based on Activity Score-dependent Metabolism by CYP2D6 and CYP2C19 Polymorphisms
BackgroundVenlafaxine (VEN) is a commonly utilized medication for alleviating depression and anxiety disorders. The presence of genetic polymorphisms...
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Sudden Unexpected Death in Epilepsy (SUDEP)
Sudden unexpected death in epilepsy (SUDEP) is a common cause of premature mortality among people with epilepsy (PWE). The overall incidence rate of...
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Drug Repurposing for Spinal Cord Injury: Progress Towards Therapeutic Intervention for Primary Factors and Secondary Complications
Spinal cord injury (SCI) encompasses a plethora of complex mechanisms like the involvement of major cell death pathways, neurodegeneration of spinal...
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De novo variants in GABRA4 are associated with a neurological phenotype including developmental delay, behavioral abnormalities and epilepsy
Nine out of 19 genes encoding GABA A receptor subunits have been linked to monogenic syndromes characterized by seizures and developmental disorders....
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Feasibility of Using Oral Fluid for Therapeutic Drug Monitoring of Antiepileptic Drugs
Therapeutic drug monitoring (TDM) of antiepileptic drugs (AED) using blood is well established but limited by its invasiveness, accessibility, cost,...
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Expression profile of synaptic vesicle glycoprotein 2A, B, and C paralogues in temporal neocortex tissue from patients with temporal lobe epilepsy (TLE)
Synaptic vesicle glycoprotein-2 (SV2) is a family of proteins consisting of SV2A, SV2B, and SV2C. This protein family has attracted attention in...
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Clinical Bridging Studies and Modeling Approach for Implementation of a Patient Centric Sampling Technique in Padsevonil Clinical Development
Volumetric absorptive microsampling (VAMS) techniques have gained popularity these last years as innovative tool for collection of blood...
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Novel Therapeutics for Neonatal Seizures
Neonatal seizures are a common neurologic emergency for which therapies have not significantly changed in decades. Improvements in diagnosis and...
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The Progress of Poststroke Seizures
A stroke is one of the most common fatal diseases of the nervous system, and the number of strokes per year has increased substantially in recent...
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Protocol for 6 Hz Corneal Stimulation in Rodents for Refractory Seizures
The 6-hertz (6 Hz) model is an effective tool to screen drugs for psychomotor seizures and/or treatment-resistant focal seizures. It is known to...
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Alzheimer’s Disease and Epilepsy: A Perspective on the Opportunities for Overlap** Therapeutic Innovation
Early-onset Alzheimer’s disease (AD) is associated with variants in amyloid precursor protein (APP) and presenilin (PSEN) 1 and 2. It is increasingly...
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Epilepsy and Other Phenotypic Features of X-Linked Intellectual Disability Due to Mutations in the KIAA2022 Gene
Objectives . To assess published data and a series of clinical cases in relation to the clinical features of epilepsy, electroencephalographic...
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Efficacy and tolerability of lacosamide as adjunctive therapy in patients with focal-onset seizures: an observational, prospective study
PurposeTo evaluate the efficacy and tolerability of adjunctive lacosamide (LCM) in patients with focal-onset seizures, with or without combined...
