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Experimental and Translational Methods to Screen Drugs Effective Against Seizures and Epilepsy

  • Book
  • © 2021

Overview

Editors:
  1. Divya Vohora

    1. Neurobehavioral Pharmacology Laboratory, Department of Pharmacology, School of Pharmaceutical Education and Research (SPER), Jamia Hamdard, New Delhi, India

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  • Includes cutting-edge methods and protocols
  • Provides step-by-step detail essential for reproducible results
  • Contains key notes and implementation advice from the experts

Part of the book series: Neuromethods (NM, volume 167)

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About this book

This volume discusses the latest experimental and clinical approaches to study seizures and epilepsy. Chapters in this book cover detailed protocols for ex vivo and in vitro experimental models and widely-used in vivo (acute and chronic seizure) models in epilepsy research. Chapters also cover techniques to screen the effective leads for the treatment of refractory seizures of pharmacoresistant epilepsy and invertebrate, non-mammalian models. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. 

Cutting-edge and practical, Experimental and Translational Methods to Screen Drugs Effective Against Seizures and Epilepsy is a valuable resource for researchers, in both industry and academia, interested in learning about this important and develo** field.



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Table of contents (13 protocols)

  1. Front Matter

    Pages i-xiv
    Download chapter PDF

  2. Models for Seizures and Epilepsy: An Overview

    1. Front Matter

      Pages 1-1
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    2. Models of Seizures and Epilepsy: Important Tools in the Discovery and Evaluation of Novel Epilepsy Therapies

      • Wolfgang Löscher
      Pages 3-7

  3. Ex Vivo and In Vitro Models

    1. Front Matter

      Pages 9-9
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    2. Protocol for Rodent Organotypic Hippocampal Slice Culture Model for Ex Vivo Monitoring of Epileptogenesis

      • Shabnam Ghiasvand, **g Liu, Md. Joynal Abedin, Yevgeny Berdichevsky
      Pages 11-28

    3. Methods for the Screening of New Chemical Entities for Deciphering Neuroinflammatory and Associated Pathways in Seizures: An In Vitro Perspective

      • Preeti Vyas, Rajkumar Tulsawani, Divya Vohora
      Pages 29-53

    4. Cellular Electrophysiological Methods to Decipher the Altered Synaptic Transmission Associated with Drug-Resistant Epilepsy

      • Soumil Dey, Aparna Banerjee Dixit, Manjari Tripathi, P. Sarat Chandra, Jyotirmoy Banerjee
      Pages 55-76

  5. Models for Refractory Seizures

    1. Front Matter

      Pages 165-165
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    2. Protocol for 6 Hz Corneal Stimulation in Rodents for Refractory Seizures

      • Razia Khanam, Divya Vohora
      Pages 167-179

    3. A Method to Induce Lamotrigine-Resistant Corneal Kindled Mice

      • Melissa Barker-Haliski
      Pages 181-199

    4. Protocol for Drug Screening with Quantitative Video-Electroencephalography in a Translational Model of Refractory Neonatal Seizures

      • Brennan J. Sullivan, Shilpa D. Kadam
      Pages 201-217

  6. Invertebrate/Non-Mammalian Models

    1. Front Matter

      Pages 219-219
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    2. Methods to Investigate Seizures and Associated Cognitive Decline Using Zebrafish Model

      • Brandon Kar Meng Choo, Mohd. Farooq Shaikh
      Pages 221-232

    3. C. elegans as a Potential Model for Acute Seizure-Like Activity

      • Alistair Jones, Anthony G. Marson, Vincent T. Cunliffe, Graeme J. Sills, Alan Morgan
      Pages 233-248

  7. Back Matter

    Pages 249-250
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Editors and Affiliations

  • Neurobehavioral Pharmacology Laboratory, Department of Pharmacology, School of Pharmaceutical Education and Research (SPER), Jamia Hamdard, New Delhi, India

    Divya Vohora

Bibliographic Information

  • Book Title: Experimental and Translational Methods to Screen Drugs Effective Against Seizures and Epilepsy

  • Editors: Divya Vohora

  • Series Title: Neuromethods

  • DOI: https://doi.org/10.1007/978-1-0716-1254-5

  • Publisher: Humana New York, NY

  • eBook Packages: Springer Protocols

  • Copyright Information: Springer Science+Business Media, LLC, part of Springer Nature 2021

  • Hardcover ISBN: 978-1-0716-1253-8Published: 08 June 2021

  • Softcover ISBN: 978-1-0716-1256-9Published: 08 June 2021

  • eBook ISBN: 978-1-0716-1254-5Published: 07 June 2021

  • Series ISSN: 0893-2336

  • Series E-ISSN: 1940-6045

  • Edition Number: 1

  • Number of Pages: XIV, 250

  • Number of Illustrations: 13 b/w illustrations, 24 illustrations in colour

  • Topics: Neurosciences

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