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Open AccessCombined emapalumab and ruxolitinib in patients with haemophagocytic Lymphohistiocytosis
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Open AccessA chromosome-level genome of electric catfish (Malapterurus electricus) provided new insights into order Siluriformes evolution
The electric catfish (Malapterurus electricus), belonging to the family Malapteruridae, order Siluriformes (Actinopterygii: Ostariophysi), is one of the six branches that has independently evolved electrical orga...
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Open AccessConstruction of a near infrared fluorescence system for imaging of biological tissues
Surgical procedures often rely on unaided visual observation or endoscopic assistance, which may pose challenges in cases involving intricate anatomical relationships. Real-time imaging technologies capable of...
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Open AccessMolecular and functional characterization of porcine poly C binding protein 1 (PCBP1)
Poly C Binding Protein 1 (PCBP1) belongs to the heterogeneous nuclear ribonucleoprotein family. It is a multifunctional protein that participates in several functional circuits and plays a variety of roles in ...
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Article
Open AccessSensory nerves directly promote osteoclastogenesis by secreting peptidyl-prolyl cis-trans isomerase D (Cyp40)
Given afferent functions, sensory nerves have recently been found to exert efferent effects and directly alter organ physiology. Additionally, several studies have highlighted the indirect but crucial role of ...
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Open AccessPKM2 is a potential prognostic biomarker and related to immune infiltration in lung cancer
Pyruvate kinase M2 (PKM2), a subtype of pyruvate kinase, plays a crucial role as a key enzyme in the final step of glycolysis. It is involved in regulating the tumor microenvironment and accelerating tumor progre...
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Open AccessCytotoxic phenazine and antiallergic phenoxazine alkaloids from an arctic Nocardiopsis dassonvillei SCSIO 502F
Microbes well-adapted to the Arctic Ocean are promising for producing novel compounds, due to their fancy strategies for adaptation and being under-investigated. Two new phenazine alkaloids (1 and 2) and one new ...
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Open AccessA single-cell atlas of West African lungfish respiratory system reveals evolutionary adaptations to terrestrialization
The six species of lungfish possess both lungs and gills and are the closest extant relatives of tetrapods. Here, we report a single-cell transcriptome atlas of the West African lungfish (Protopterus annectens). ...
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Open AccessIdentification of Fangjihuangqi Decoction as a late-stage autophagy inhibitor with an adjuvant anti-tumor effect against non-small cell lung cancer
Clinically, although chemotherapy is one of the most commonly used methods of treating tumors, chemotherapeutic drugs can induce autophagic flux and increase tumor cell resistance, leading to drug tolerance. T...
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TLR2-mediated NF-κB signaling pathway is involved in PPV1-induced apoptosis in PK-15 cells
Porcine parvovirus 1 (PPV1) mainly induces severe reproductive failure in pregnant swine, and causes huge economic losses to the swine industry. Cell apoptosis induced by PPV1 infection has been identified the...
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Open AccessMultiparameter prediction model of immune checkpoint inhibitors combined with chemotherapy for non-small cell lung cancer based on support vector machine learning
The reliable predictive markers to identify which patients with advanced non-small cell lung cancer tumors (NSCLC) will achieve durable clinical benefit (DCB) for chemo-immunotherapy are needed. In this retros...
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Open AccessCan mobile-bearing unicompartmental knee arthroplasty achieve natural gap-balancing? An observational study with a novel pressure sensor
Mobile-bearing unicompartmental knee arthroplasty (MB-UKA) is an effective treatment for anteromedial knee osteoarthritis. Meticulous intraoperative soft tissue balancing remains challenging yet consequential ...
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Open AccessCavitation assisted endoplasmic reticulum targeted sonodynamic droplets to enhanced anti-PD-L1 immunotherapy in pancreatic cancer
Sonodynamic therapy (SDT) induces immunogenic cell death (ICD) in tumors and promises to play an assistive role in immunotherapy in pancreatic cancer. However, the short half-life and limited diffusion distanc...
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Open AccessIntegrated analysis reveals the pivotal interactions between immune cells in the melanoma tumor microenvironment
Melanoma is the most lethal type of skin cancer. Despite the breakthroughs in the clinical treatment of melanoma using tumor immunotherapy, many patients do not benefit from these immunotherapies because of mu...
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Open AccessA novel self-learning weighted fuzzy local information clustering algorithm integrating local and non-local spatial information for noise image segmentation
Fuzzy clustering algorithm (FCM) can be directly used to segment images, it takes no account of the neighborhood information of the current pixel and does not have a robust segmentation noise suppression. Fuzz...
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Open AccessPhytonanotechnology applications in modern agriculture
With the rapidly changing global climate, the agricultural systems are confronted with more unpredictable and harsh environmental conditions than before which lead to compromised food production. Thus, to ensu...
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Retraction Note: Real-time water quality prediction model based on fine-grained image classification and home aerobic exercise rehabilitation for the elderly
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Open AccessMechanosensitive cation channel Piezo1 contributes to ventilator-induced lung injury by activating RhoA/ROCK1 in rats
Mechanical ventilation can induce or aggravate lung injury, which is termed ventilator-induced lung injury (VILI). Piezo1 is a key element of the mechanotransduction process and can transduce mechanical signal...
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Open AccessComparison of multichannel signal deconvolution algorithms in airborne LiDAR bathymetry based on wavelet transform
Airborne LiDAR bathymetry offers low cost and high mobility, making it an ideal option for shallow-water measurements. However, due to differences in the measurement environment and the laser emission channel,...
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Open AccessPIWIL2 interacting with IKK to regulate autophagy and apoptosis in esophageal squamous cell carcinoma
Esophageal squamous cell carcinoma (ESCC) is one of the most common malignancies and cause of death from cancer in China. Previous studies showed that autophagy and apoptosis inhibition are critical for the su...
