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Article
Open AccessCombined emapalumab and ruxolitinib in patients with haemophagocytic Lymphohistiocytosis
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Article
Understanding of the Microstructure Evolution and Wear Resistance of Cr12MoV Die Steel during Deep Cryogenic Treatment
The present study investigated the influence of deep cryogenic treatment (DCT) on the microstructure evolution and wear resistance of Cr12MoV die steel. Four types of heat treatments (quenching + tempering (QT...
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Article
Successful Treatment of Refractory EBV-Associated Hemophagocytic Lymphohistiocytosis with Combined Emapalumab and PD-1 Blockade
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Article
Open AccessA chromosome-level genome of electric catfish (Malapterurus electricus) provided new insights into order Siluriformes evolution
The electric catfish (Malapterurus electricus), belonging to the family Malapteruridae, order Siluriformes (Actinopterygii: Ostariophysi), is one of the six branches that has independently evolved electrical orga...
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Article
Open AccessConstruction of a near infrared fluorescence system for imaging of biological tissues
Surgical procedures often rely on unaided visual observation or endoscopic assistance, which may pose challenges in cases involving intricate anatomical relationships. Real-time imaging technologies capable of...
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Article
Open AccessMolecular and functional characterization of porcine poly C binding protein 1 (PCBP1)
Poly C Binding Protein 1 (PCBP1) belongs to the heterogeneous nuclear ribonucleoprotein family. It is a multifunctional protein that participates in several functional circuits and plays a variety of roles in ...
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Chapter and Conference Paper
Small-Sample Coal-Rock Recognition Model Based on MFSC and Siamese Neural Network
Given the advantages of deep learning in feature extraction and learning ability, it has been used in coal-rock recognition. Deep learning techniques rely on a large number of independent identically distribut...
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Chapter and Conference Paper
Effects of Heat Treatment Processes on the Microstructure and Properties of 20CrMo Alloy Steel
A correlation study and analysis were carried out on the microstructure, mechanical properties, and hardness of 20CrMo alloy steel with different secondary quenching processes. The results indicate that, when ...
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Article
Open AccessSensory nerves directly promote osteoclastogenesis by secreting peptidyl-prolyl cis-trans isomerase D (Cyp40)
Given afferent functions, sensory nerves have recently been found to exert efferent effects and directly alter organ physiology. Additionally, several studies have highlighted the indirect but crucial role of ...
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Article
Open AccessPKM2 is a potential prognostic biomarker and related to immune infiltration in lung cancer
Pyruvate kinase M2 (PKM2), a subtype of pyruvate kinase, plays a crucial role as a key enzyme in the final step of glycolysis. It is involved in regulating the tumor microenvironment and accelerating tumor progre...
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Article
Open AccessCytotoxic phenazine and antiallergic phenoxazine alkaloids from an arctic Nocardiopsis dassonvillei SCSIO 502F
Microbes well-adapted to the Arctic Ocean are promising for producing novel compounds, due to their fancy strategies for adaptation and being under-investigated. Two new phenazine alkaloids (1 and 2) and one new ...
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Article
Open AccessA single-cell atlas of West African lungfish respiratory system reveals evolutionary adaptations to terrestrialization
The six species of lungfish possess both lungs and gills and are the closest extant relatives of tetrapods. Here, we report a single-cell transcriptome atlas of the West African lungfish (Protopterus annectens). ...
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Article
Neuronal and astrocytic CB1R signaling differentially modulates goal-directed behavior and working memory by distinct temporal mechanisms
Several cognitive processes, including instrumental behavior and working memory, are controlled by endocannabinoids acting on cannabinoid receptor 1 (CB1R) in the brain through retrograde and presynaptic inhib...
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Article
Berbamine Hydrochloride inhibits lysosomal acidification by activating Nox2 to potentiate chemotherapy-induced apoptosis via the ROS-MAPK pathway in human lung carcinoma cells
Autophagy is typically activated in cancer cells as a rescue strategy in response to cellular stress (e.g., chemotherapy). Herein, we found that Berbamine Hydrochloride (Ber) can act as an effective inhibitor ...
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Article
Open AccessIdentification of Fangjihuangqi Decoction as a late-stage autophagy inhibitor with an adjuvant anti-tumor effect against non-small cell lung cancer
Clinically, although chemotherapy is one of the most commonly used methods of treating tumors, chemotherapeutic drugs can induce autophagic flux and increase tumor cell resistance, leading to drug tolerance. T...
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Article
TLR2-mediated NF-κB signaling pathway is involved in PPV1-induced apoptosis in PK-15 cells
Porcine parvovirus 1 (PPV1) mainly induces severe reproductive failure in pregnant swine, and causes huge economic losses to the swine industry. Cell apoptosis induced by PPV1 infection has been identified the...
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Article
Open AccessMultiparameter prediction model of immune checkpoint inhibitors combined with chemotherapy for non-small cell lung cancer based on support vector machine learning
The reliable predictive markers to identify which patients with advanced non-small cell lung cancer tumors (NSCLC) will achieve durable clinical benefit (DCB) for chemo-immunotherapy are needed. In this retros...
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Article
Correlation between ultrasonographic scores and American college of rheumatology recommended rheumatoid arthritis disease activity measures: a systematic review and network meta-analysis
To validate and facilitate ultrasound examinations on rheumatoid arthritis (RA) disease activity measurements in routine clinical practice.
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Article
Artificial potential field guided JPS algorithm for fast optimal path planning in cluttered environments
This paper focuses on the path planning improvement for mobile robots in cluttered environments. Due to the uncertainty of searching direction in traditional path planning algorithms, each node often searches ...
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Article
Research on the buffering measure of rock shed against the impact of dry granular flow with concern of structure damage
Dry granular flow induced by rock collapses and landslides is a typical disaster in mountainous areas. Rock sheds are widely used as protective structures to shield traffic lines against the impacts of rockfal...
