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Article
Open AccessSorafenib inhibits ossification of the posterior longitudinal ligament by blocking LOXL2-mediated vascularization
Ossification of the Posterior Longitudinal Ligament (OPLL) is a degenerative hyperostosis disease characterized by the transformation of the soft and elastic vertebral ligament into bone, resulting in limited ...
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Chapter and Conference Paper
Cup-Disk Ratio Segmentation Joint with Key Retinal Vascular Information Under Diagnostic and Screening Scenarios
Glaucoma is one of the leading causes of irreversible blindness worldwide. Numerous studies have shown that a larger vertical Cup-to-Disc Ratio (CDR) is closely associated with the glaucoma diagnosis. CDR is h...
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Chapter and Conference Paper
Byzantine-Robust Privacy-Preserving Federated Learning Based on DT-PKC
Federated Learning (FL) offers a solution that enables multiple clients to jointly train machine learning models while maintaining data privacy by only uploading model information instead of local data. Howeve...
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Article
Open AccessPKM2 is a potential prognostic biomarker and related to immune infiltration in lung cancer
Pyruvate kinase M2 (PKM2), a subtype of pyruvate kinase, plays a crucial role as a key enzyme in the final step of glycolysis. It is involved in regulating the tumor microenvironment and accelerating tumor progre...
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Article
Open AccessGeo-environmental and mechanical behaviors of As(V) and Cd(II) co-contaminated soils stabilized by goethite nanoparticles modified biochar
Goethite nanoparticles modified biochar (FBC) could address the weak effectiveness of conventional biochar commonly to process heavy metal(loids) (HMs) co-contamination with different charges. However, few st...
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Article
Predicting the diagnosis of various mental disorders in a mixed cohort using blood-based multi-protein model: a machine learning approach
The lack of objective diagnostic methods for mental disorders challenges the reliability of diagnosis. The study aimed to develop an easily accessible and useable objective method for diagnosing major depressi...
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Article
Open AccessHuman mobility patterns are associated with experienced partisan segregation in US metropolitan areas
Partisan sorting in residential environments is an enduring feature of contemporary American politics, but little research has examined partisan segregation individuals experience in activity spaces through th...
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Article
Mechanical properties evolution and microscopic mechanisms of arsenic and cadmium co-contaminated clayey soils
Understanding the interaction mechanism between different heavy metals and soils is a primary and important task for remediation of contaminated soils. In this study, we conducted series experiments to explore...
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Article
Open AccessGenomic patterns linked to gray matter alterations underlying working memory deficits in adults and adolescents with attention-deficit/hyperactivity disorder
Attention-deficit/hyperactivity disorder (ADHD) is a highly heritable neurodevelopmental disorder, with onset in childhood and a considerable likelihood to persist into adulthood. Our previous work has identif...
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Article
Open AccessChild maltreatment exposure and adolescent nonsuicidal self-injury: the mediating roles of difficulty in emotion regulation and depressive symptoms
Although child maltreatment (CM) experiences are recognized risk factors for nonsuicidal self-injury (NSSI), the mechanisms underlying this relationship remain unclear. The purpose of this study was to examine...
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Article
Open AccessSpatially resolved proteomics via tissue expansion
Spatially resolved proteomics is an emerging approach for map** proteome heterogeneity of biological samples, however, it remains technically challenging due to the complexity of the tissue microsampling tec...
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Article
A novel NPHS2 mutation (c.865A > G) identified in a Chinese family with steroid-resistant nephrotic syndrome alters subcellular localization of nephrin
NPHS2 is the causative gene of nephrotic syndrome type 2 (MIM 600995) which often clinically manifests as steroid-resistant nephrotic syndrome (SRNS). The NPHS2 gene encodes a slit diaphragm (SD) associated prote...
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Article
Open AccessPGE2 activates EP4 in subchondral bone osteoclasts to regulate osteoarthritis
Prostaglandin E2 (PGE2), a major cyclooxygenase-2 (COX-2) product, is highly secreted by the osteoblast lineage in the subchondral bone tissue of osteoarthritis (OA) patients. However, NSAIDs, including COX-2 ...
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Article
Open AccessA novel prostaglandin E receptor 4 (EP4) small molecule antagonist induces articular cartilage regeneration
Articular cartilage repair and regeneration is an unmet clinical need because of the poor self-regeneration capacity of the tissue. In this study, we found that the expression of prostaglandin E receptor 4 (PT...
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Article
Open AccessNavigation-guided nasal endoscopic surgery for acute vision loss caused by fibrous dysplasia: a case report and review of literatures
Bone fibrous dysplasia is a benign disease of bone tissue dysplasia. Vision impairment is the commonest neurological complication of craniofacial fibrous dysplasia. Most of the vision loss caused by craniofaci...
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Article
Open AccessPIWIL2 interacting with IKK to regulate autophagy and apoptosis in esophageal squamous cell carcinoma
Esophageal squamous cell carcinoma (ESCC) is one of the most common malignancies and cause of death from cancer in China. Previous studies showed that autophagy and apoptosis inhibition are critical for the su...
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Article
Open AccessGray matter networks associated with attention and working memory deficit in ADHD across adolescence and adulthood
Attention-deficit/hyperactivity disorder (ADHD) is a childhood-onset neuropsychiatric disorder and may persist into adulthood. Working memory and attention deficits have been reported to persist from childhood...
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Chapter
Comparison of PAE with Other Treatments in BPH
Currently, various treatment options are available for lower urinary tract symptoms (LUTS) secondary to benign prostatic hyperplasia (BPH), mainly including medical therapy, open prostatectomy (OP), transureth...
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Article
Fine-grained hand gesture recognition based on active acoustic signal for VR systems
Hand gestures are the nature and dominant interaction interfaces for VR systems. The state of the art interaction mechanism for VR system either requires expensive sensing devices or suffers from accuracy issu...
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Article
Deep-Learning-Based Segmentation and Localization of White Matter Hyperintensities on Magnetic Resonance Images
White matter magnetic resonance hyperintensities of presumed vascular origin, which could be widely observed in elderly people, and has significant importance in multiple neurological studies. Quantitative mea...
